| pubmed-article:14695834 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:14695834 | lifeskim:mentions | umls-concept:C0596402 | lld:lifeskim |
| pubmed-article:14695834 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:14695834 | lifeskim:mentions | umls-concept:C0103301 | lld:lifeskim |
| pubmed-article:14695834 | lifeskim:mentions | umls-concept:C0142946 | lld:lifeskim |
| pubmed-article:14695834 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:14695834 | pubmed:dateCreated | 2003-12-29 | lld:pubmed |
| pubmed-article:14695834 | pubmed:abstractText | Tumor tissues have an acidic microenvironment with a pH from 6.0 to 7.0, whereas the intra- and extracellular milieu of normal cells is 7.4. We have found that the hydrolysis of sodium trioxodinitrate (Angeli's salt; 1) to hydroxyl radical (*OH) was 10 times higher at pH = 6.0 than at pH = 7.4. It is hypothesized that the formation of *OH in solutions of 1 reflects the hydrolysis of the latter compound to nitroxyl (HNO) which dimerizes to cis-hyponitrous acid (HO-N=N-OH; 3) with concomitant azo-type homolytic fission to N(2) and *OH. In weakly acidified solutions, 1 exhibited strong toxicity to cancer cells that was inhibited by scavengers of hydroxyl radical, whereas no toxicity was observed at pH = 7.4. In a subcutaneous xenograft model of pheochromocytoma, 1 markedly inhibited tumor growth at a dose that was nontoxic to nude mice. These data suggest that the H(+)-amplified production of *OH from 1, and maybe other precursors of HNO, could be a selective mechanism for destruction cells with an acidic intra- or extracellular microenvironment. | lld:pubmed |
| pubmed-article:14695834 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14695834 | pubmed:language | eng | lld:pubmed |
| pubmed-article:14695834 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14695834 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:14695834 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14695834 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14695834 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14695834 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14695834 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:14695834 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:14695834 | pubmed:issn | 0022-2623 | lld:pubmed |
| pubmed-article:14695834 | pubmed:author | pubmed-author:NylanderKaren... | lld:pubmed |
| pubmed-article:14695834 | pubmed:author | pubmed-author:StoyanovskyDe... | lld:pubmed |
| pubmed-article:14695834 | pubmed:author | pubmed-author:SalamaGuyG | lld:pubmed |
| pubmed-article:14695834 | pubmed:author | pubmed-author:SchorNina FNF | lld:pubmed |
| pubmed-article:14695834 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:14695834 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:14695834 | pubmed:volume | 47 | lld:pubmed |
| pubmed-article:14695834 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:14695834 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:14695834 | pubmed:pagination | 210-7 | lld:pubmed |
| pubmed-article:14695834 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:14695834 | pubmed:meshHeading | pubmed-meshheading:14695834... | lld:pubmed |
| pubmed-article:14695834 | pubmed:meshHeading | pubmed-meshheading:14695834... | lld:pubmed |
| pubmed-article:14695834 | pubmed:meshHeading | pubmed-meshheading:14695834... | lld:pubmed |
| pubmed-article:14695834 | pubmed:meshHeading | pubmed-meshheading:14695834... | lld:pubmed |
| pubmed-article:14695834 | pubmed:meshHeading | pubmed-meshheading:14695834... | lld:pubmed |
| pubmed-article:14695834 | pubmed:meshHeading | pubmed-meshheading:14695834... | lld:pubmed |
| pubmed-article:14695834 | pubmed:meshHeading | pubmed-meshheading:14695834... | lld:pubmed |
| pubmed-article:14695834 | pubmed:meshHeading | pubmed-meshheading:14695834... | lld:pubmed |
| pubmed-article:14695834 | pubmed:meshHeading | pubmed-meshheading:14695834... | lld:pubmed |
| pubmed-article:14695834 | pubmed:meshHeading | pubmed-meshheading:14695834... | lld:pubmed |
| pubmed-article:14695834 | pubmed:meshHeading | pubmed-meshheading:14695834... | lld:pubmed |
| pubmed-article:14695834 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:14695834 | pubmed:articleTitle | Effects of pH on the cytotoxicity of sodium trioxodinitrate (Angeli's salt). | lld:pubmed |
| pubmed-article:14695834 | pubmed:affiliation | Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA. stoyanovskyd@msx.upmc.edu | lld:pubmed |
| pubmed-article:14695834 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:14695834 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:14695834 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:14695834 | lld:chembl |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14695834 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14695834 | lld:pubmed |
