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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2003-12-29
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pubmed:abstractText |
A novel primase inhibitor, Sch 642305 (1), was isolated from the fermentation broth of the fungal culture Penicillium verrucosum. The structure of 1 was elucidated on the basis of MS and NMR spectroscopic data as a new and unusual bicyclic 10-membered macrolide. The absolute configuration of the asymmetric centers was determined by X-ray crystallographic analysis of the p-bromobenzoate derivative (3). Compound 1 exhibited inhibitory activity against bacterial DNA primase enzyme with an EC(50) of 70 microM.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0163-3864
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pubmed:author |
pubmed-author:BlackToddT,
pubmed-author:ChanTze-MingTM,
pubmed-author:ChuMinM,
pubmed-author:GulloVincentV,
pubmed-author:HeLingL,
pubmed-author:LingXuX,
pubmed-author:McPhailAndrew TAT,
pubmed-author:MierzwaRonaldR,
pubmed-author:PatelMaheshM,
pubmed-author:TerraccianoJosephJ,
pubmed-author:ZhaoWenjunW
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pubmed:issnType |
Print
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pubmed:volume |
66
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1527-30
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:14695789-Arizona,
pubmed-meshheading:14695789-Crystallography, X-Ray,
pubmed-meshheading:14695789-DNA Primase,
pubmed-meshheading:14695789-Enzyme Inhibitors,
pubmed-meshheading:14695789-Fermentation,
pubmed-meshheading:14695789-Macrolides,
pubmed-meshheading:14695789-Molecular Conformation,
pubmed-meshheading:14695789-Molecular Structure,
pubmed-meshheading:14695789-Nuclear Magnetic Resonance, Biomolecular,
pubmed-meshheading:14695789-Penicillium
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pubmed:year |
2003
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pubmed:articleTitle |
Isolation and structure elucidation of Sch 642305, a novel bacterial DNA primase inhibitor produced by Penicillium verrucosum.
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pubmed:affiliation |
Schering-Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, USA. min.chu@spcorp.com
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pubmed:publicationType |
Journal Article
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