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pubmed-article:14695350pubmed:abstractTextBecause vagal and sympathetic inputs activate upper cervical spinal neurons, we hypothesized that stimulation of the esophagus would activate C(1)-C(2) neurons. This study examined responses of C(1)-C(2) spinal neurons to cervical and thoracic esophageal distension (CED, TED) and afferent pathways for CED and TED inputs to C(1)-C(2) spinal neurons. Extracellular potentials of single C(1)-C(2) spinal neurons were recorded in pentobarbital-anesthetized male rats. Graded CED or TED was produced by water inflation (0.1-0.5 ml) of a latex balloon. CED changed activity of 48/219 (22%) neurons; 34 were excited (E), 12 were inhibited (I), and 2 were E-I. CED elicited responses for 18/18 neurons tested after ipsilateral cervical vagotomy, for 12/14 neurons tested after bilateral vagotomy and for 9/11 neurons tested after bilateral vagotomy and C(6)-C(7) spinal cord transection. TED changed activity of 31/190 (16%) neurons (28E, 3 I). Ipsilateral cervical vagotomy abolished TED-evoked responses of 5/12 neurons. Bilateral vagotomy eliminated responses of 2/4 neurons tested, and C(6)-C(7) spinal transection plus bilateral vagotomy eliminated responses of 2/2 neurons. Thus inputs from CED to C(1)-C(2) neurons most likely entered upper cervical dorsal roots, whereas inputs from TED were dependent on vagal pathways and/or sympathetic afferent pathways that entered the thoracic dorsal roots. These results supported a concept that C(1)-C(2) spinal neurons play a role in integrating visceral information from cervical and thoracic esophagus.lld:pubmed
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pubmed-article:14695350pubmed:authorpubmed-author:DealW RWRlld:pubmed
pubmed-article:14695350pubmed:authorpubmed-author:ChandlerMarga...lld:pubmed
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pubmed-article:14695350pubmed:pagination2227-35lld:pubmed
pubmed-article:14695350pubmed:dateRevised2007-11-14lld:pubmed
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pubmed-article:14695350pubmed:year2004lld:pubmed
pubmed-article:14695350pubmed:articleTitleResponses and afferent pathways of C1-C2 spinal neurons to cervical and thoracic esophageal stimulation in rats.lld:pubmed
pubmed-article:14695350pubmed:affiliationDepartment of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73190, USA. chao-qin@ouhsc.edulld:pubmed
pubmed-article:14695350pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:14695350pubmed:publicationTypeComparative Studylld:pubmed
pubmed-article:14695350pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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