pubmed-article:14695350 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:14695350 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
pubmed-article:14695350 | lifeskim:mentions | umls-concept:C0027882 | lld:lifeskim |
pubmed-article:14695350 | lifeskim:mentions | umls-concept:C0817096 | lld:lifeskim |
pubmed-article:14695350 | lifeskim:mentions | umls-concept:C0205064 | lld:lifeskim |
pubmed-article:14695350 | lifeskim:mentions | umls-concept:C0001728 | lld:lifeskim |
pubmed-article:14695350 | lifeskim:mentions | umls-concept:C1522619 | lld:lifeskim |
pubmed-article:14695350 | lifeskim:mentions | umls-concept:C0521329 | lld:lifeskim |
pubmed-article:14695350 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
pubmed-article:14695350 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
pubmed-article:14695350 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
pubmed-article:14695350 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
pubmed-article:14695350 | lifeskim:mentions | umls-concept:C1948023 | lld:lifeskim |
pubmed-article:14695350 | pubmed:issue | 5 | lld:pubmed |
pubmed-article:14695350 | pubmed:dateCreated | 2004-4-7 | lld:pubmed |
pubmed-article:14695350 | pubmed:abstractText | Because vagal and sympathetic inputs activate upper cervical spinal neurons, we hypothesized that stimulation of the esophagus would activate C(1)-C(2) neurons. This study examined responses of C(1)-C(2) spinal neurons to cervical and thoracic esophageal distension (CED, TED) and afferent pathways for CED and TED inputs to C(1)-C(2) spinal neurons. Extracellular potentials of single C(1)-C(2) spinal neurons were recorded in pentobarbital-anesthetized male rats. Graded CED or TED was produced by water inflation (0.1-0.5 ml) of a latex balloon. CED changed activity of 48/219 (22%) neurons; 34 were excited (E), 12 were inhibited (I), and 2 were E-I. CED elicited responses for 18/18 neurons tested after ipsilateral cervical vagotomy, for 12/14 neurons tested after bilateral vagotomy and for 9/11 neurons tested after bilateral vagotomy and C(6)-C(7) spinal cord transection. TED changed activity of 31/190 (16%) neurons (28E, 3 I). Ipsilateral cervical vagotomy abolished TED-evoked responses of 5/12 neurons. Bilateral vagotomy eliminated responses of 2/4 neurons tested, and C(6)-C(7) spinal transection plus bilateral vagotomy eliminated responses of 2/2 neurons. Thus inputs from CED to C(1)-C(2) neurons most likely entered upper cervical dorsal roots, whereas inputs from TED were dependent on vagal pathways and/or sympathetic afferent pathways that entered the thoracic dorsal roots. These results supported a concept that C(1)-C(2) spinal neurons play a role in integrating visceral information from cervical and thoracic esophagus. | lld:pubmed |
pubmed-article:14695350 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:14695350 | pubmed:language | eng | lld:pubmed |
pubmed-article:14695350 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:14695350 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:14695350 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:14695350 | pubmed:month | May | lld:pubmed |
pubmed-article:14695350 | pubmed:issn | 0022-3077 | lld:pubmed |
pubmed-article:14695350 | pubmed:author | pubmed-author:DealW RWR | lld:pubmed |
pubmed-article:14695350 | pubmed:author | pubmed-author:ChandlerMarga... | lld:pubmed |
pubmed-article:14695350 | pubmed:author | pubmed-author:ForemanRobert... | lld:pubmed |
pubmed-article:14695350 | pubmed:author | pubmed-author:JouChuanchau... | lld:pubmed |
pubmed-article:14695350 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:14695350 | pubmed:volume | 91 | lld:pubmed |
pubmed-article:14695350 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:14695350 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:14695350 | pubmed:pagination | 2227-35 | lld:pubmed |
pubmed-article:14695350 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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pubmed-article:14695350 | pubmed:year | 2004 | lld:pubmed |
pubmed-article:14695350 | pubmed:articleTitle | Responses and afferent pathways of C1-C2 spinal neurons to cervical and thoracic esophageal stimulation in rats. | lld:pubmed |
pubmed-article:14695350 | pubmed:affiliation | Department of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73190, USA. chao-qin@ouhsc.edu | lld:pubmed |
pubmed-article:14695350 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:14695350 | pubmed:publicationType | Comparative Study | lld:pubmed |
pubmed-article:14695350 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14695350 | lld:pubmed |