Source:http://linkedlifedata.com/resource/pubmed/id/14695350
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
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| pubmed:dateCreated |
2004-4-7
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| pubmed:abstractText |
Because vagal and sympathetic inputs activate upper cervical spinal neurons, we hypothesized that stimulation of the esophagus would activate C(1)-C(2) neurons. This study examined responses of C(1)-C(2) spinal neurons to cervical and thoracic esophageal distension (CED, TED) and afferent pathways for CED and TED inputs to C(1)-C(2) spinal neurons. Extracellular potentials of single C(1)-C(2) spinal neurons were recorded in pentobarbital-anesthetized male rats. Graded CED or TED was produced by water inflation (0.1-0.5 ml) of a latex balloon. CED changed activity of 48/219 (22%) neurons; 34 were excited (E), 12 were inhibited (I), and 2 were E-I. CED elicited responses for 18/18 neurons tested after ipsilateral cervical vagotomy, for 12/14 neurons tested after bilateral vagotomy and for 9/11 neurons tested after bilateral vagotomy and C(6)-C(7) spinal cord transection. TED changed activity of 31/190 (16%) neurons (28E, 3 I). Ipsilateral cervical vagotomy abolished TED-evoked responses of 5/12 neurons. Bilateral vagotomy eliminated responses of 2/4 neurons tested, and C(6)-C(7) spinal transection plus bilateral vagotomy eliminated responses of 2/2 neurons. Thus inputs from CED to C(1)-C(2) neurons most likely entered upper cervical dorsal roots, whereas inputs from TED were dependent on vagal pathways and/or sympathetic afferent pathways that entered the thoracic dorsal roots. These results supported a concept that C(1)-C(2) spinal neurons play a role in integrating visceral information from cervical and thoracic esophagus.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:status |
MEDLINE
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| pubmed:month |
May
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| pubmed:issn |
0022-3077
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
91
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
2227-35
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| pubmed:dateRevised |
2007-11-14
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| pubmed:meshHeading |
pubmed-meshheading:14695350-Afferent Pathways,
pubmed-meshheading:14695350-Animals,
pubmed-meshheading:14695350-Cervical Vertebrae,
pubmed-meshheading:14695350-Ear, External,
pubmed-meshheading:14695350-Esophagus,
pubmed-meshheading:14695350-Head,
pubmed-meshheading:14695350-Male,
pubmed-meshheading:14695350-Neck,
pubmed-meshheading:14695350-Neurons,
pubmed-meshheading:14695350-Physical Stimulation,
pubmed-meshheading:14695350-Rats,
pubmed-meshheading:14695350-Rats, Sprague-Dawley,
pubmed-meshheading:14695350-Shoulder,
pubmed-meshheading:14695350-Skin,
pubmed-meshheading:14695350-Spinal Cord,
pubmed-meshheading:14695350-Stereotaxic Techniques,
pubmed-meshheading:14695350-Thoracic Vertebrae,
pubmed-meshheading:14695350-Vagus Nerve
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| pubmed:year |
2004
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| pubmed:articleTitle |
Responses and afferent pathways of C1-C2 spinal neurons to cervical and thoracic esophageal stimulation in rats.
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| pubmed:affiliation |
Department of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73190, USA. chao-qin@ouhsc.edu
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| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.
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