| pubmed-article:14695260 | rdf:type | pubmed:Citation | lld:pubmed |
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| pubmed-article:14695260 | lifeskim:mentions | umls-concept:C0205276 | lld:lifeskim |
| pubmed-article:14695260 | lifeskim:mentions | umls-concept:C0030685 | lld:lifeskim |
| pubmed-article:14695260 | lifeskim:mentions | umls-concept:C0205100 | lld:lifeskim |
| pubmed-article:14695260 | lifeskim:mentions | umls-concept:C0001272 | lld:lifeskim |
| pubmed-article:14695260 | lifeskim:mentions | umls-concept:C0596235 | lld:lifeskim |
| pubmed-article:14695260 | lifeskim:mentions | umls-concept:C0680255 | lld:lifeskim |
| pubmed-article:14695260 | lifeskim:mentions | umls-concept:C0391871 | lld:lifeskim |
| pubmed-article:14695260 | lifeskim:mentions | umls-concept:C1283071 | lld:lifeskim |
| pubmed-article:14695260 | lifeskim:mentions | umls-concept:C1963578 | lld:lifeskim |
| pubmed-article:14695260 | lifeskim:mentions | umls-concept:C0205171 | lld:lifeskim |
| pubmed-article:14695260 | lifeskim:mentions | umls-concept:C1521990 | lld:lifeskim |
| pubmed-article:14695260 | pubmed:issue | 1 Pt 1 | lld:pubmed |
| pubmed-article:14695260 | pubmed:dateCreated | 2003-12-25 | lld:pubmed |
| pubmed-article:14695260 | pubmed:abstractText | Ca2+ release from the endoplasmic reticulum (ER) contributes to Ca2+ transients in frog sympathetic ganglion neurons. Here we use video-rate confocal fluo-4 fluorescence imaging to show that single action potentials reproducibly trigger rapidly rising Ca2+ transients at 1-3 local hot spots within the peripheral ER-rich layer in intact neurons in fresh ganglia and in the majority (74%) of cultured neurons. Hot spots were located near the nucleus or the axon hillock region. Other regions exhibited either slower and smaller signals or no response. Ca2+ signals spread into the cell at constant velocity across the ER in nonnuclear regions, indicating active propagation, but spread with a (time)1/2 dependence within the nucleus, consistent with diffusion. 26% of cultured cells exhibited uniform Ca2+ signals around the periphery, but hot spots were produced by loading the cytosol with EGTA or by bathing such cells in low-Ca2+ Ringer's solution. Peripheral hot spots for Ca2+ release within the perinuclear and axon hillock regions provide a mechanism for preferential initiation of nuclear and axonal Ca2+ signals by single action potentials in sympathetic ganglion neurons. | lld:pubmed |
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| pubmed-article:14695260 | pubmed:language | eng | lld:pubmed |
| pubmed-article:14695260 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14695260 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:14695260 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:14695260 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:14695260 | pubmed:issn | 0006-3495 | lld:pubmed |
| pubmed-article:14695260 | pubmed:author | pubmed-author:SchneiderMart... | lld:pubmed |
| pubmed-article:14695260 | pubmed:author | pubmed-author:CseresnyésZol... | lld:pubmed |
| pubmed-article:14695260 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:14695260 | pubmed:volume | 86 | lld:pubmed |
| pubmed-article:14695260 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:14695260 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:14695260 | pubmed:pagination | 163-81 | lld:pubmed |
| pubmed-article:14695260 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:14695260 | pubmed:meshHeading | pubmed-meshheading:14695260... | lld:pubmed |
| pubmed-article:14695260 | pubmed:meshHeading | pubmed-meshheading:14695260... | lld:pubmed |
| pubmed-article:14695260 | pubmed:meshHeading | pubmed-meshheading:14695260... | lld:pubmed |
| pubmed-article:14695260 | pubmed:meshHeading | pubmed-meshheading:14695260... | lld:pubmed |
| pubmed-article:14695260 | pubmed:meshHeading | pubmed-meshheading:14695260... | lld:pubmed |
| pubmed-article:14695260 | pubmed:meshHeading | pubmed-meshheading:14695260... | lld:pubmed |
| pubmed-article:14695260 | pubmed:meshHeading | pubmed-meshheading:14695260... | lld:pubmed |
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| pubmed-article:14695260 | pubmed:meshHeading | pubmed-meshheading:14695260... | lld:pubmed |
| pubmed-article:14695260 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:14695260 | pubmed:articleTitle | Peripheral hot spots for local Ca2+ release after single action potentials in sympathetic ganglion neurons. | lld:pubmed |
| pubmed-article:14695260 | pubmed:affiliation | Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, Maryland, USA. | lld:pubmed |
| pubmed-article:14695260 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:14695260 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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