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rdf:type |
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lifeskim:mentions |
|
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pubmed:issue |
17
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pubmed:dateCreated |
2003-12-25
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pubmed:abstractText |
Recently, it was reported that BRAF mutations are frequent in melanoma. Previously, we analyzed a large series of paired primary and metastatic melanomas for NRAS codon 61 mutations and showed that they arise early and are preserved during tumor progression. Here, we have screened the same tumor samples for BRAF mutations.
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1078-0432
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
6483-8
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:14695152-Adult,
pubmed-meshheading:14695152-Aged,
pubmed-meshheading:14695152-Codon,
pubmed-meshheading:14695152-DNA,
pubmed-meshheading:14695152-DNA Mutational Analysis,
pubmed-meshheading:14695152-Disease Progression,
pubmed-meshheading:14695152-Exons,
pubmed-meshheading:14695152-Female,
pubmed-meshheading:14695152-Genes, ras,
pubmed-meshheading:14695152-Humans,
pubmed-meshheading:14695152-MAP Kinase Signaling System,
pubmed-meshheading:14695152-Male,
pubmed-meshheading:14695152-Melanoma,
pubmed-meshheading:14695152-Middle Aged,
pubmed-meshheading:14695152-Mutation,
pubmed-meshheading:14695152-Neoplasm Metastasis,
pubmed-meshheading:14695152-Polymorphism, Single-Stranded Conformational,
pubmed-meshheading:14695152-Proto-Oncogene Proteins B-raf,
pubmed-meshheading:14695152-Proto-Oncogene Proteins c-raf,
pubmed-meshheading:14695152-Treatment Outcome
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pubmed:year |
2003
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pubmed:articleTitle |
NRAS and BRAF mutations arise early during melanoma pathogenesis and are preserved throughout tumor progression.
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pubmed:affiliation |
Cancer Centre Karolinska, Department of Oncology-Pathology, Radiumhemmet, Karolinska Hospital and Institute, Stockholm, Sweden.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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