| pubmed-article:1469467 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1469467 | lifeskim:mentions | umls-concept:C0013216 | lld:lifeskim |
| pubmed-article:1469467 | lifeskim:mentions | umls-concept:C0031268 | lld:lifeskim |
| pubmed-article:1469467 | lifeskim:mentions | umls-concept:C0017638 | lld:lifeskim |
| pubmed-article:1469467 | lifeskim:mentions | umls-concept:C0311400 | lld:lifeskim |
| pubmed-article:1469467 | lifeskim:mentions | umls-concept:C0392747 | lld:lifeskim |
| pubmed-article:1469467 | lifeskim:mentions | umls-concept:C0032743 | lld:lifeskim |
| pubmed-article:1469467 | lifeskim:mentions | umls-concept:C0681814 | lld:lifeskim |
| pubmed-article:1469467 | lifeskim:mentions | umls-concept:C0260193 | lld:lifeskim |
| pubmed-article:1469467 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:1469467 | pubmed:dateCreated | 1993-1-25 | lld:pubmed |
| pubmed-article:1469467 | pubmed:abstractText | To shed light on the metabolic changes in glioma following therapy, uptake changes among 18F-fluoro-2'-deoxyuridine (18FUdR), 14C-thymidine (dThd), 14C-methionine (Met) and 3H-deoxyglucose (DG) in glioma model after chemotherapy were studied, as a means for interpreting clinical PET results, together with the changes in the bromodeoxyuridine (BUdR) labeling index. 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(-2chloroethyl)-3-nitro sourea hydrochloride (ACNU) was administered intraperitoneally in the tumor-bearing rats and uptake of the tracers or BUdR labeling index in tumor tissue were measured. The metabolic response following chemotherapy was a sharp fall immediately for 14C-dThd and 18FUdR and a moderate fall for 14C-Met whereas there was a fall in 3H-DG from 1 week after chemotherapy. The changes of BUdR labeling index paralleled that in the uptake for dThd and FUdR. These result indicate that PET scans using a variety of tracers in conjunction could be used for clinical diagnosis and evaluation of therapy in glioma cases. 18FUdR is a promising tracer of nucleic acid metabolism to evaluate the proliferative potential of brain gliomas. | lld:pubmed |
| pubmed-article:1469467 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1469467 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1469467 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1469467 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1469467 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1469467 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1469467 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1469467 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1469467 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1469467 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1469467 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1469467 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1469467 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1469467 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1469467 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1469467 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:1469467 | pubmed:issn | 0167-594X | lld:pubmed |
| pubmed-article:1469467 | pubmed:author | pubmed-author:YoshimotoTT | lld:pubmed |
| pubmed-article:1469467 | pubmed:author | pubmed-author:SatoKK | lld:pubmed |
| pubmed-article:1469467 | pubmed:author | pubmed-author:IshiwataKK | lld:pubmed |
| pubmed-article:1469467 | pubmed:author | pubmed-author:KatakuraRR | lld:pubmed |
| pubmed-article:1469467 | pubmed:author | pubmed-author:KameyamaMM | lld:pubmed |
| pubmed-article:1469467 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1469467 | pubmed:volume | 14 | lld:pubmed |
| pubmed-article:1469467 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1469467 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1469467 | pubmed:pagination | 81-9 | lld:pubmed |
| pubmed-article:1469467 | pubmed:dateRevised | 2003-11-14 | lld:pubmed |
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| pubmed-article:1469467 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1469467 | pubmed:articleTitle | Metabolic changes of glioma following chemotherapy: an experimental study using four PET tracers. | lld:pubmed |
| pubmed-article:1469467 | pubmed:affiliation | Division of Neurosurgery, Tohoku University School of Medicine, Japan. | lld:pubmed |
| pubmed-article:1469467 | pubmed:publicationType | Journal Article | lld:pubmed |
