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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1993-1-25
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pubmed:abstractText |
To shed light on the metabolic changes in glioma following therapy, uptake changes among 18F-fluoro-2'-deoxyuridine (18FUdR), 14C-thymidine (dThd), 14C-methionine (Met) and 3H-deoxyglucose (DG) in glioma model after chemotherapy were studied, as a means for interpreting clinical PET results, together with the changes in the bromodeoxyuridine (BUdR) labeling index. 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(-2chloroethyl)-3-nitro sourea hydrochloride (ACNU) was administered intraperitoneally in the tumor-bearing rats and uptake of the tracers or BUdR labeling index in tumor tissue were measured. The metabolic response following chemotherapy was a sharp fall immediately for 14C-dThd and 18FUdR and a moderate fall for 14C-Met whereas there was a fall in 3H-DG from 1 week after chemotherapy. The changes of BUdR labeling index paralleled that in the uptake for dThd and FUdR. These result indicate that PET scans using a variety of tracers in conjunction could be used for clinical diagnosis and evaluation of therapy in glioma cases. 18FUdR is a promising tracer of nucleic acid metabolism to evaluate the proliferative potential of brain gliomas.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Carbon Radioisotopes,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/Deoxyglucose,
http://linkedlifedata.com/resource/pubmed/chemical/Floxuridine,
http://linkedlifedata.com/resource/pubmed/chemical/Fluorine Radioisotopes,
http://linkedlifedata.com/resource/pubmed/chemical/Methionine,
http://linkedlifedata.com/resource/pubmed/chemical/Neoplasm Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nimustine,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/Thymidine,
http://linkedlifedata.com/resource/pubmed/chemical/Tritium
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0167-594X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
14
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
81-9
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:1469467-Animals,
pubmed-meshheading:1469467-Body Weight,
pubmed-meshheading:1469467-Carbon Radioisotopes,
pubmed-meshheading:1469467-DNA, Neoplasm,
pubmed-meshheading:1469467-DNA Replication,
pubmed-meshheading:1469467-Deoxyglucose,
pubmed-meshheading:1469467-Dose-Response Relationship, Drug,
pubmed-meshheading:1469467-Floxuridine,
pubmed-meshheading:1469467-Fluorine Radioisotopes,
pubmed-meshheading:1469467-Glioma,
pubmed-meshheading:1469467-Groin,
pubmed-meshheading:1469467-Male,
pubmed-meshheading:1469467-Methionine,
pubmed-meshheading:1469467-Neoplasm Proteins,
pubmed-meshheading:1469467-Neoplasm Transplantation,
pubmed-meshheading:1469467-Nimustine,
pubmed-meshheading:1469467-RNA, Neoplasm,
pubmed-meshheading:1469467-Rats,
pubmed-meshheading:1469467-Rats, Wistar,
pubmed-meshheading:1469467-Survival Rate,
pubmed-meshheading:1469467-Thymidine,
pubmed-meshheading:1469467-Tomography, Emission-Computed,
pubmed-meshheading:1469467-Tritium
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pubmed:year |
1992
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pubmed:articleTitle |
Metabolic changes of glioma following chemotherapy: an experimental study using four PET tracers.
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pubmed:affiliation |
Division of Neurosurgery, Tohoku University School of Medicine, Japan.
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pubmed:publicationType |
Journal Article
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