Linked Life Data

14694343

Source:http://linkedlifedata.com/resource/pubmed/id/14694343

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1 Suppl
pubmed:dateCreated
2003-12-24
pubmed:abstractText
In the past few decades, a number of epidemiologic studies have identified risk factors for the development of allergic disease. Although both maternal and paternal history of allergy are associated with an increased risk of atopy, maternal history of asthma confers the greater risk for childhood asthma, which suggests that environmental factors such as the in utero immunologic environment may confer additional susceptibility. Cytokine profiles at birth may also indicate a predisposition to allergic disease in later childhood. Specifically, low interferon-gamma appears to be associated with an increased risk for later development of allergic symptoms and atopic disease. Allergen exposure may also increase the risk of atopic consequences, but the outcome is highly dependent on dose of the allergen, timing of exposure, and, most interestingly, the nature of the allergen in question. Endotoxin exposure during infancy has been associated with increased wheezing during the first years of life, but several studies indicate that early exposure may confer some protection against allergy later in life. Clearly, all these factors should be evaluated in identifying the appropriate prevention measures and treatment for the child who is at risk for allergic disease.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0091-6749
pubmed:author
pubmed:issnType
Print
pubmed:volume
113
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
S2-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
The epidemiology of the atopic child: who is at risk for what?
pubmed:affiliation
Arizona Respiratory Center, Department of Pediatrics, University of Arizona, Tucson, Arizona 85724, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Review