| pubmed-article:14691244 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:14691244 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:14691244 | lifeskim:mentions | umls-concept:C0002074 | lld:lifeskim |
| pubmed-article:14691244 | lifeskim:mentions | umls-concept:C0069197 | lld:lifeskim |
| pubmed-article:14691244 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:14691244 | pubmed:dateCreated | 2003-12-23 | lld:pubmed |
| pubmed-article:14691244 | pubmed:abstractText | O(6)-alkylguanine-DNA alkyltransferase (AGT) repairs pro-mutagenic O(6)-alkylguanine and O(4)-alkylthymine lesions in DNA. The alkylated form of the protein is not reactivated; instead, it is rapidly ubiquitinated and degraded. Here, we show that alkylation destabilizes the native fold of the protein by 0.5-1.2 kcal/mole and the DNA-binding function by 0.8-1.4 kcal/mole. On this basis, we propose that destabilization of the native conformational ensemble acts as a signal for ubiquitination. | lld:pubmed |
| pubmed-article:14691244 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14691244 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14691244 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14691244 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14691244 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14691244 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14691244 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14691244 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14691244 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14691244 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14691244 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14691244 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14691244 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14691244 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14691244 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14691244 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14691244 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14691244 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14691244 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14691244 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14691244 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14691244 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14691244 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14691244 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14691244 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14691244 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14691244 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14691244 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14691244 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14691244 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14691244 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14691244 | pubmed:language | eng | lld:pubmed |
| pubmed-article:14691244 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14691244 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:14691244 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14691244 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14691244 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14691244 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14691244 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14691244 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:14691244 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:14691244 | pubmed:issn | 0961-8368 | lld:pubmed |
| pubmed-article:14691244 | pubmed:author | pubmed-author:PeggAnthony... | lld:pubmed |
| pubmed-article:14691244 | pubmed:author | pubmed-author:FriedMichael... | lld:pubmed |
| pubmed-article:14691244 | pubmed:author | pubmed-author:RasimasJoseph... | lld:pubmed |
| pubmed-article:14691244 | pubmed:author | pubmed-author:RopsonIra JIJ | lld:pubmed |
| pubmed-article:14691244 | pubmed:author | pubmed-author:DalessioPaula... | lld:pubmed |
| pubmed-article:14691244 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:14691244 | pubmed:volume | 13 | lld:pubmed |
| pubmed-article:14691244 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:14691244 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:14691244 | pubmed:pagination | 301-5 | lld:pubmed |
| pubmed-article:14691244 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:14691244 | pubmed:meshHeading | pubmed-meshheading:14691244... | lld:pubmed |
| pubmed-article:14691244 | pubmed:meshHeading | pubmed-meshheading:14691244... | lld:pubmed |
| pubmed-article:14691244 | pubmed:meshHeading | pubmed-meshheading:14691244... | lld:pubmed |
| pubmed-article:14691244 | pubmed:meshHeading | pubmed-meshheading:14691244... | lld:pubmed |
| pubmed-article:14691244 | pubmed:meshHeading | pubmed-meshheading:14691244... | lld:pubmed |
| pubmed-article:14691244 | pubmed:meshHeading | pubmed-meshheading:14691244... | lld:pubmed |
| pubmed-article:14691244 | pubmed:meshHeading | pubmed-meshheading:14691244... | lld:pubmed |
| pubmed-article:14691244 | pubmed:meshHeading | pubmed-meshheading:14691244... | lld:pubmed |
| pubmed-article:14691244 | pubmed:meshHeading | pubmed-meshheading:14691244... | lld:pubmed |
| pubmed-article:14691244 | pubmed:meshHeading | pubmed-meshheading:14691244... | lld:pubmed |
| pubmed-article:14691244 | pubmed:meshHeading | pubmed-meshheading:14691244... | lld:pubmed |
| pubmed-article:14691244 | pubmed:meshHeading | pubmed-meshheading:14691244... | lld:pubmed |
| pubmed-article:14691244 | pubmed:meshHeading | pubmed-meshheading:14691244... | lld:pubmed |
| pubmed-article:14691244 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:14691244 | pubmed:articleTitle | Active-site alkylation destabilizes human O6-alkylguanine DNA alkyltransferase. | lld:pubmed |
| pubmed-article:14691244 | pubmed:affiliation | Department of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA. | lld:pubmed |
| pubmed-article:14691244 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:14691244 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14691244 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14691244 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14691244 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14691244 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14691244 | lld:pubmed |
