Linked Life Data

14690859

Source:http://linkedlifedata.com/resource/pubmed/id/14690859

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
2003-12-23
pubmed:abstractText
Acute herpes simplex virus (HSV) infection causes apoptosis in the adrenal cortex and myenteric plexus of the gut, ovary, pituitary gland, and liver of mice. Apoptosis of infected cells is increased in immunosuppressed regions of the adrenal cortex and liver of macrophage-depleted mice. HSV carries the US3 gene which interferes with host cell apoptosis. When the livers of macrophage-depleted mice are infected with a US3-null virus, apoptosis occurs in the narrow areas of inflammatory cell infiltration, restricting viral replication and spread. Thus, these data suggest that apoptosis may function as a primitive immune response to HSV infection in mice.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0883-0185
pubmed:author
pubmed:issnType
Print
pubmed:volume
23
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
173-85
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:articleTitle
A role for apoptosis induced by acute herpes simplex virus infection in mice.
pubmed:affiliation
Department of Anatomy, Teikyo University School of Medicine, 2-11-1 kaga, Itabashi-Ku, Tokyo, 173-8605, Japan. h-irie@rb3.s0-net.ne.jp
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't