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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2003-12-23
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pubmed:abstractText |
Drug reactions are well-known complications of antidepressant therapy, often related to photosensitization. Herein is reported a singular case of antidepressant (amoxapine and citalopram) and anxiolytic related (perphenazine) photo-distributed neutrophilic dermatosis and adult respiratory distress syndrome (ARDS). The clinicopathologic findings displayed overlapping features with drug-induced Sweet's syndrome, acute generalized exanthematous pustulosis (AGEP), and so-called sterile neutrophilic folliculitis with perifollicular vasculopathy. Of the three medications, only amoxapine has been associated with AGEP. Treatment with high-dose systemic corticosteroids and cessation of drug therapy was followed by rapid resolution of the cutaneous eruption and respiratory distress. The possibility that neutrophil infiltration of the lung and/or accumulation of neutrophils in the skin and blood served as a source for reactive oxygen species, leading to lung injury and subsequent ARDS, is discussed.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0303-6987
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
31
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
189-94
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:14690466-Acute Disease,
pubmed-meshheading:14690466-Adult,
pubmed-meshheading:14690466-Amoxapine,
pubmed-meshheading:14690466-Antidepressive Agents, Second-Generation,
pubmed-meshheading:14690466-Antipsychotic Agents,
pubmed-meshheading:14690466-Citalopram,
pubmed-meshheading:14690466-Diagnosis, Differential,
pubmed-meshheading:14690466-Drug Eruptions,
pubmed-meshheading:14690466-Drug Therapy, Combination,
pubmed-meshheading:14690466-Female,
pubmed-meshheading:14690466-Glucocorticoids,
pubmed-meshheading:14690466-Humans,
pubmed-meshheading:14690466-Neutrophils,
pubmed-meshheading:14690466-Perphenazine,
pubmed-meshheading:14690466-Respiratory Distress Syndrome, Adult,
pubmed-meshheading:14690466-Sweet Syndrome
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pubmed:year |
2004
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pubmed:articleTitle |
Photo-distributed neutrophilic drug eruption and adult respiratory distress syndrome associated with antidepressant therapy.
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pubmed:affiliation |
Division of Dermatology and Division of Dermatopathology, Albany Medical College, Albany, NY, USA.
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pubmed:publicationType |
Journal Article,
Case Reports
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