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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2003-12-22
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pubmed:abstractText |
Cytokine polymorphisms may modulate immunologic reactivity, including graft-versus-host disease (GVHD). A single nucleotide polymorphism resulting in a thymine-to-guanine transition in the interleukin (IL)-2 gene promoter region occurs at position -330. In vitro studies have shown that the G allele is associated with early and sustained enhancement of IL-2 production, a so-called high-producer genotype. Because IL-2 is a proinflammatory cytokine, we hypothesized that recipients with high-producer genotypes would have increased frequency of GVHD after allogeneic bone marrow transplantation (BMT).
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0041-1337
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
27
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pubmed:volume |
76
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1758-62
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:14688528-Acute Disease,
pubmed-meshheading:14688528-Adolescent,
pubmed-meshheading:14688528-Adult,
pubmed-meshheading:14688528-Bone Marrow Transplantation,
pubmed-meshheading:14688528-Child,
pubmed-meshheading:14688528-Child, Preschool,
pubmed-meshheading:14688528-Female,
pubmed-meshheading:14688528-Genotype,
pubmed-meshheading:14688528-Graft vs Host Disease,
pubmed-meshheading:14688528-Histocompatibility Testing,
pubmed-meshheading:14688528-Humans,
pubmed-meshheading:14688528-Infant,
pubmed-meshheading:14688528-Interleukin-2,
pubmed-meshheading:14688528-Male,
pubmed-meshheading:14688528-Middle Aged,
pubmed-meshheading:14688528-Probability,
pubmed-meshheading:14688528-Risk Factors,
pubmed-meshheading:14688528-Tissue Donors,
pubmed-meshheading:14688528-Transplantation Conditioning
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pubmed:year |
2003
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pubmed:articleTitle |
High-producer interleukin-2 genotype increases risk for acute graft-versus-host disease after unrelated donor bone marrow transplantation.
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pubmed:affiliation |
Department of Pediatrics, University of Minnesota, MMC 484, 420 Delaware Street SE, Minneapolis, MN 55455, USA. macmi002@umn.edu
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pubmed:publicationType |
Journal Article
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