Source:http://linkedlifedata.com/resource/pubmed/id/14687036
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
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| pubmed:dateCreated |
2003-12-22
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| pubmed:abstractText |
Acute chest syndrome (ACS) is a life-threatening complication of sickle cell disease (SCD). A retrospective study was performed to evaluate the role of endothelial nitric oxide synthase (eNOS) gene polymorphisms (E298D and T-786C) in African-American SCD patients. The D298 allele showed no association; the C-786 allele showed a statistically significant association (P = 0.0061) in female ACS cases. Multiple logistic regression analysis showed that relative risk of ACS was 8.695 (P = 0.0076, 95% confidence interval 1.761-42.920) for female carriers of C-786. eNOS T-786C is a gender-specific genetic modifier that is associated with increased susceptibility to ACS in female SCD patients.
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| pubmed:grant | |
| pubmed:commentsCorrections | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
0007-1048
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
124
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
240-3
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| pubmed:dateRevised |
2007-11-14
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| pubmed:meshHeading |
pubmed-meshheading:14687036-Acute Disease,
pubmed-meshheading:14687036-Adolescent,
pubmed-meshheading:14687036-Adult,
pubmed-meshheading:14687036-Aged,
pubmed-meshheading:14687036-Anemia, Sickle Cell,
pubmed-meshheading:14687036-Chest Pain,
pubmed-meshheading:14687036-Female,
pubmed-meshheading:14687036-Genetic Predisposition to Disease,
pubmed-meshheading:14687036-Genotype,
pubmed-meshheading:14687036-Humans,
pubmed-meshheading:14687036-Male,
pubmed-meshheading:14687036-Middle Aged,
pubmed-meshheading:14687036-Nitric Oxide Synthase,
pubmed-meshheading:14687036-Nitric Oxide Synthase Type III,
pubmed-meshheading:14687036-Polymorphism, Genetic,
pubmed-meshheading:14687036-Retrospective Studies,
pubmed-meshheading:14687036-Sequence Analysis, DNA,
pubmed-meshheading:14687036-Syndrome
|
| pubmed:year |
2004
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| pubmed:articleTitle |
Association of T-786C eNOS gene polymorphism with increased susceptibility to acute chest syndrome in females with sickle cell disease.
|
| pubmed:affiliation |
Division of Hematology and Cardeza Foundation for Hematologic Research, Department of Medicine, Jefferson Medical College, 7th Floor Curtis Building, 1015 Walnut Street, Philadelphia, PA 19107, USA.
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| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|