Linked Life Data

14686956

Source:http://linkedlifedata.com/resource/pubmed/id/14686956

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2003-12-22
pubmed:abstractText
Coronary heart disease (CHD) is a major cause of mortality in the Western world. CHD risk is known to be modified by both genetic and environmental factors. In this review, we look at the role of lipoprotein lipase (LPL) gene variants in predisposing to CHD risk and the important interaction between these genotypes and environmental factors (e.g. smoking). Gene-environmental interactions result in a greater than additive effect on risk and understanding these gene-environmental interactions has the potential not only for improving our understanding of the pathophysiology of the disease, but also in the development of new therapies and the targeting of specific therapies. For example, if a genotype increases risk in a particular environment, then those subjects would be encouraged to change their lifestyles more aggressively. Similarly at-risk subjects could be targeted with available therapies more appropriately.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
1462-8902
pubmed:author
pubmed:issnType
Print
pubmed:volume
6
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1-7
pubmed:dateRevised
2009-11-3
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Lipoprotein lipase gene variants and the effect of environmental factors on cardiovascular disease risk.
pubmed:affiliation
Centre for Cardiovascular Genetics, British Heart Foundation Laboratories, Department of Medicine, Royal Free and University College Medical School, London, UK. p.talmud@ucl.ac.uk
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't