Source:http://linkedlifedata.com/resource/pubmed/id/14686902
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
12
|
| pubmed:dateCreated |
2003-12-22
|
| pubmed:abstractText |
Herpes simplex virus type 1 (HSV-1) is the major pathogen related to epilepsy. However, little is known about the pathogenesis of HSV-1-associated epilepsy. Here, we report that corneal inoculation of mice with HSV-1 induces acute spontaneous behavioural and electrophysiological seizures and chronically increases hippocampal excitability and seizure susceptibility. In slices from infected mice, the surviving hippocampal CA3 pyramidal neurons exhibited a more depolarizing resting membrane potential concomitant with an increase in membrane input resistance. They also had a lower threshold for generating synchronized bursts and a decrease in the amplitude of afterhyperpolarization (AHP) than did controls. These results suggest that a direct change in the excitability of the hippocampal CA3 neuronal network could play an important role in facilitating the development of acute seizures and subsequent epilepsy.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
0953-816X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
18
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
3294-304
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:14686902-Action Potentials,
pubmed-meshheading:14686902-Animals,
pubmed-meshheading:14686902-Causality,
pubmed-meshheading:14686902-Cell Membrane,
pubmed-meshheading:14686902-Disease Models, Animal,
pubmed-meshheading:14686902-Disease Susceptibility,
pubmed-meshheading:14686902-Electric Impedance,
pubmed-meshheading:14686902-Encephalitis, Herpes Simplex,
pubmed-meshheading:14686902-Epilepsy,
pubmed-meshheading:14686902-Epilepsy, Temporal Lobe,
pubmed-meshheading:14686902-Herpesvirus 1, Human,
pubmed-meshheading:14686902-Hippocampus,
pubmed-meshheading:14686902-Kainic Acid,
pubmed-meshheading:14686902-Male,
pubmed-meshheading:14686902-Mice,
pubmed-meshheading:14686902-Mice, Inbred BALB C,
pubmed-meshheading:14686902-Neural Pathways,
pubmed-meshheading:14686902-Organ Culture Techniques,
pubmed-meshheading:14686902-Pyramidal Cells,
pubmed-meshheading:14686902-Viral Proteins
|
| pubmed:year |
2003
|
| pubmed:articleTitle |
Herpes simplex virus type 1 inoculation enhances hippocampal excitability and seizure susceptibility in mice.
|
| pubmed:affiliation |
Department of Pharmacology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|