Linked Life Data

14685899

Source:http://linkedlifedata.com/resource/pubmed/id/14685899

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2003-12-19
pubmed:abstractText
Major histocompatibility antigens (MHC) play a crucial role in the recognition of tumor cells by the immune system. There is not much information on the role of MHC molecule expression in primary orbital melanomas. In the present study, the authors examined the expression of human leukocyte antigen (HLA) class I, beta(2)-microglobulin (beta(2)-m) and HLA class II antigens in primary orbital melanoma and correlated this with the clinical and pathological findings. HLA class I antigen, beta(2)-m and HLA class II antigen expression were evaluated immunohistochemically in three primary orbital melanomas and correlated with cell type and metastasis. Immunohistochemistry showed heterogeneous expression of HLA class I, beta(2)-m and HLA class II antigen in two cases with no liver metastasis and negative expression in one case with liver metastasis. This preliminary observation deserves further investigation, which may shed more light on the immune escape mechanisms of this tumor and thus make possible novel therapeutic strategies.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0167-6830
pubmed:author
pubmed:issnType
Print
pubmed:volume
22
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
257-63
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
Expression of HLA class I, beta(2)-microglobulin and HLA class II antigens in primary orbital melanoma.
pubmed:affiliation
Ocular Pathology laboratory, Medical and Vision Research Foundations, Chennai, Sankara Nethralaya, India.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't