Source:http://linkedlifedata.com/resource/pubmed/id/14685887
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
9
|
| pubmed:dateCreated |
2004-10-18
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| pubmed:abstractText |
The capability of modern imaging techniques such as CT, MRI, US and US-guided fine-needle aspiration cytology (USgFNAC) to detect small tumour deposits is limited. Therefore, the detection of occult metastases in the clinically negative neck remains a diagnostic problem. One of the novel options to refine staging of head and neck cancer is [(18)F]fluorodeoxyglucose positron emission tomography (FDG-PET). To evaluate the diagnostic value of FDG-PET in the detection of occult malignant lymph nodes, we compared the results of FDG-PET with other diagnostic techniques and the histopathological outcome of 15 neck dissection specimens from 15 head and neck cancer patients with a clinically negative neck. Three sides contained metastases of squamous cell carcinoma. FDG-PET enabled detection of metastases in two sides, which were also detected by MRI or USgFNAC. FDG-PET and CT missed metastases in one patient, which were detected by both MRI and USgFNAC. In studies with a detailed examination of lymph nodes of a neck dissection, a low sensitivity of FDG-PET for the detection of occult lymph node metastases is found. It is unlikely that FDG-PET is superior in the detection of occult lymph node metastases in head and neck cancer patients with a palpably negative neck. The histopathological method used seems to be the most important factor for the differences in sensitivity in reported FDG-PET studies. New approaches such as the use of monoclonal antibodies labelled with a positron emitter may improve the results of PET in these patients.
|
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
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| pubmed:issn |
0937-4477
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
261
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
479-83
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:14685887-Adult,
pubmed-meshheading:14685887-Aged,
pubmed-meshheading:14685887-Biopsy, Needle,
pubmed-meshheading:14685887-Carcinoma, Squamous Cell,
pubmed-meshheading:14685887-Female,
pubmed-meshheading:14685887-Fluorodeoxyglucose F18,
pubmed-meshheading:14685887-Follow-Up Studies,
pubmed-meshheading:14685887-Humans,
pubmed-meshheading:14685887-Immunohistochemistry,
pubmed-meshheading:14685887-Lymph Nodes,
pubmed-meshheading:14685887-Magnetic Resonance Imaging,
pubmed-meshheading:14685887-Male,
pubmed-meshheading:14685887-Middle Aged,
pubmed-meshheading:14685887-Mouth Neoplasms,
pubmed-meshheading:14685887-Neoplasm Staging,
pubmed-meshheading:14685887-Pharyngeal Neoplasms,
pubmed-meshheading:14685887-Positron-Emission Tomography,
pubmed-meshheading:14685887-Risk Assessment,
pubmed-meshheading:14685887-Sampling Studies,
pubmed-meshheading:14685887-Sensitivity and Specificity,
pubmed-meshheading:14685887-Tomography, X-Ray Computed
|
| pubmed:year |
2004
|
| pubmed:articleTitle |
Positron emission tomography using [18F]fluorodeoxyglucose (FDG-PET) in the clinically negative neck: is it likely to be superior?
|
| pubmed:affiliation |
Department of Otolaryngology and Head and Neck Surgery, VU University Medical Center, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands.
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| pubmed:publicationType |
Journal Article,
Comparative Study
|