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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2003-12-19
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pubmed:abstractText |
Over 50 phenyl thiazolyl urea and carbamate derivatives were synthesized for evaluation as new inhibitors of bacterial cell-wall biosynthesis. Many of them demonstrated good activity against MurA and MurB and gram-positive bacteria including MRSA, VRE and PRSP. 3,4-Difluorophenyl 5-cyanothiazolylurea (3p) with clog P of 2.64 demonstrated antibacterial activity against both gram-positive and gram-negative bacteria.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0960-894X
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pubmed:author |
pubmed-author:AlbrightJ DonaldJD,
pubmed-author:EudyNancy HNH,
pubmed-author:FranciscoGerardo DGD,
pubmed-author:KatzAlan HAH,
pubmed-author:LabthavikulPornpenP,
pubmed-author:LinYang-IYI,
pubmed-author:MansourTarek STS,
pubmed-author:PetersenPeter JPJ,
pubmed-author:RasmussenBeth ABA,
pubmed-author:SinghGuyG,
pubmed-author:YangYoujunY,
pubmed-author:ZhongLiL
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|
pubmed:issnType |
Print
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|
pubmed:day |
5
|
|
pubmed:volume |
14
|
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pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
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pubmed:pagination |
235-8
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pubmed:meshHeading |
|
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pubmed:year |
2004
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pubmed:articleTitle |
Phenyl thiazolyl urea and carbamate derivatives as new inhibitors of bacterial cell-wall biosynthesis.
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pubmed:affiliation |
Chemical Sciences and Infectious Diseases, Wyeth Research, Pearl River, NY 10965, USA.
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pubmed:publicationType |
Journal Article
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