Linked Life Data

14684331

Source:http://linkedlifedata.com/resource/pubmed/id/14684331

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:14684331rdf:typepubmed:Citationlld:pubmed
pubmed-article:14684331lifeskim:mentionsumls-concept:C2752508lld:lifeskim
pubmed-article:14684331lifeskim:mentionsumls-concept:C1383501lld:lifeskim
pubmed-article:14684331lifeskim:mentionsumls-concept:C1167322lld:lifeskim
pubmed-article:14684331lifeskim:mentionsumls-concept:C0007036lld:lifeskim
pubmed-article:14684331lifeskim:mentionsumls-concept:C0022173lld:lifeskim
pubmed-article:14684331lifeskim:mentionsumls-concept:C0038760lld:lifeskim
pubmed-article:14684331lifeskim:mentionsumls-concept:C0450442lld:lifeskim
pubmed-article:14684331lifeskim:mentionsumls-concept:C0879271lld:lifeskim
pubmed-article:14684331pubmed:issue1lld:pubmed
pubmed-article:14684331pubmed:dateCreated2003-12-19lld:pubmed
pubmed-article:14684331pubmed:abstractTextE7070 [N-(3-chloro-7-indolyl)-1,4-benzenedisulfonamide] is an anticancer drug candidate under clinical development for the treatment of several types of cancers. We prove here that this compound also acts as a potent carbonic anhydrase (CA) inhibitor. Similarly to the clinically used drugs acetazolamide, methazolamide and topiramate, E7070 showed inhibition constants in the range of 15-31nM against isozymes I, II and IX, being slightly less effective as a CA IV inhibitor (K(i) of 65nM). The X-ray crystal structure of the adduct of hCA II with E7070 revealed unprecedented interactions between the inhibitor and the active site, with three different conformations of the chloroindole fragment of the inhibitor interacting with different amino acid residues/water molecules of the enzyme. A superimposition of these conformations with those of other sulfonamide/sulfamate CA inhibitors indicated that similar regions of the hCA II active site could be involved in the interaction with inhibitors.lld:pubmed
pubmed-article:14684331pubmed:languageenglld:pubmed
pubmed-article:14684331pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14684331pubmed:citationSubsetIMlld:pubmed
pubmed-article:14684331pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14684331pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14684331pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14684331pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14684331pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14684331pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14684331pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14684331pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14684331pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14684331pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14684331pubmed:statusMEDLINElld:pubmed
pubmed-article:14684331pubmed:monthJanlld:pubmed
pubmed-article:14684331pubmed:issn0960-894Xlld:pubmed
pubmed-article:14684331pubmed:authorpubmed-author:ScozzafavaAnd...lld:pubmed
pubmed-article:14684331pubmed:authorpubmed-author:SupuranClaudi...lld:pubmed
pubmed-article:14684331pubmed:authorpubmed-author:AbbateFrances...lld:pubmed
pubmed-article:14684331pubmed:authorpubmed-author:CasiniAngelaAlld:pubmed
pubmed-article:14684331pubmed:authorpubmed-author:OwaTakashiTlld:pubmed
pubmed-article:14684331pubmed:issnTypePrintlld:pubmed
pubmed-article:14684331pubmed:day5lld:pubmed
pubmed-article:14684331pubmed:volume14lld:pubmed
pubmed-article:14684331pubmed:ownerNLMlld:pubmed
pubmed-article:14684331pubmed:authorsCompleteYlld:pubmed
pubmed-article:14684331pubmed:pagination217-23lld:pubmed
pubmed-article:14684331pubmed:dateRevised2004-11-17lld:pubmed
pubmed-article:14684331pubmed:meshHeadingpubmed-meshheading:14684331...lld:pubmed
pubmed-article:14684331pubmed:meshHeadingpubmed-meshheading:14684331...lld:pubmed
pubmed-article:14684331pubmed:meshHeadingpubmed-meshheading:14684331...lld:pubmed
pubmed-article:14684331pubmed:meshHeadingpubmed-meshheading:14684331...lld:pubmed
pubmed-article:14684331pubmed:meshHeadingpubmed-meshheading:14684331...lld:pubmed
pubmed-article:14684331pubmed:meshHeadingpubmed-meshheading:14684331...lld:pubmed
pubmed-article:14684331pubmed:meshHeadingpubmed-meshheading:14684331...lld:pubmed
pubmed-article:14684331pubmed:meshHeadingpubmed-meshheading:14684331...lld:pubmed
pubmed-article:14684331pubmed:meshHeadingpubmed-meshheading:14684331...lld:pubmed
pubmed-article:14684331pubmed:meshHeadingpubmed-meshheading:14684331...lld:pubmed
pubmed-article:14684331pubmed:meshHeadingpubmed-meshheading:14684331...lld:pubmed
pubmed-article:14684331pubmed:meshHeadingpubmed-meshheading:14684331...lld:pubmed
pubmed-article:14684331pubmed:meshHeadingpubmed-meshheading:14684331...lld:pubmed
pubmed-article:14684331pubmed:meshHeadingpubmed-meshheading:14684331...lld:pubmed
pubmed-article:14684331pubmed:year2004lld:pubmed
pubmed-article:14684331pubmed:articleTitleCarbonic anhydrase inhibitors: E7070, a sulfonamide anticancer agent, potently inhibits cytosolic isozymes I and II, and transmembrane, tumor-associated isozyme IX.lld:pubmed
pubmed-article:14684331pubmed:affiliationUniversità degli Studi di Firenze, Polo Scientifico, Dipartimento di Chimica, Laboratorio di Chimica Bioinorganica, Via della Lastruccia 3, Rm. 188, I-50019 Sesto Fiorentino, Florence, Italy.lld:pubmed
pubmed-article:14684331pubmed:publicationTypeJournal Articlelld:pubmed
http://linkedlifedata.com/r...http://linkedlifedata.com/r...pubmed-article:14684331lld:chembl
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:14684331lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:14684331lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:14684331lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:14684331lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:14684331lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:14684331lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:14684331lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:14684331lld:pubmed