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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2003-12-19
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pubmed:abstractText |
Inhibition of the sodium hydrogen exchanger isoform-1 (NHE-1) has been shown to limit damage to the myocardium under ischemic conditions in animals. While most known NHE-1 inhibitors are acylguanidines, this report describes the design and synthesis of a series of heterocyclic inhibitors of NHE-1 including aminoimidazoles with undiminished in vitro activity and oral bioavailability.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0960-894X
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pubmed:author |
pubmed-author:AhmadSaleemS,
pubmed-author:AtwalKarnail SKS,
pubmed-author:ChandrasenaGaminiG,
pubmed-author:ChenBang-ChiBC,
pubmed-author:CombsDonald WDW,
pubmed-author:DorsoCharles RCR,
pubmed-author:KirbyMarkM,
pubmed-author:LiuWenW,
pubmed-author:NguKhehyongK,
pubmed-author:WeinsteinDavid SDS,
pubmed-author:WuShung CSC
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pubmed:issnType |
Print
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pubmed:day |
5
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pubmed:volume |
14
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
177-80
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:14684323-Administration, Oral,
pubmed-meshheading:14684323-Biological Availability,
pubmed-meshheading:14684323-Cation Transport Proteins,
pubmed-meshheading:14684323-Cell Line,
pubmed-meshheading:14684323-Guanidines,
pubmed-meshheading:14684323-Humans,
pubmed-meshheading:14684323-Imidazoles,
pubmed-meshheading:14684323-Membrane Proteins,
pubmed-meshheading:14684323-Protein Isoforms,
pubmed-meshheading:14684323-Sodium-Hydrogen Antiporter,
pubmed-meshheading:14684323-Stereoisomerism
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pubmed:year |
2004
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pubmed:articleTitle |
Aminoimidazoles as bioisosteres of acylguanidines: novel, potent, selective and orally bioavailable inhibitors of the sodium hydrogen exchanger isoform-1.
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pubmed:affiliation |
Bristol-Myers Squibb Pharmaceutical Research Institute, PO Box 4000, Princeton, NJ 08543, USA. saleem.ahmad@bms.com
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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