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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2003-12-19
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pubmed:abstractText |
Structure-activity relationship (SAR) studies of 2-[3-di(and tri)fluoromethyl-5-arylpyrazol-1-yl]-5-methanesulfonylpyridine derivatives for canine COX enzymes are described. This led to the identification of 12a as a lead candidate for further progression. The in vitro and in vivo activity of 12a for the canine COX-2 enzyme as well as its in vivo efficacy and pharmacokinetic properties in dog are highlighted.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0960-894X
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pubmed:author |
pubmed-author:BronkBrian SBS,
pubmed-author:CallaghanKathleen MKM,
pubmed-author:ChengHenryH,
pubmed-author:CrossonRhonda MRM,
pubmed-author:DeMelloKristin M LundyKM,
pubmed-author:DutraJason KJK,
pubmed-author:HavenMichelle LML,
pubmed-author:JaynesBurton HBH,
pubmed-author:KilroyCarolynC,
pubmed-author:KirkGlen WGW,
pubmed-author:KoloskoNicole LNL,
pubmed-author:KossDavid ADA,
pubmed-author:LiChaoC,
pubmed-author:LohWW,
pubmed-author:LundLisa ALA,
pubmed-author:LynchMichael PMP,
pubmed-author:MannDonald WDW,
pubmed-author:MinichMartha LML,
pubmed-author:MortonBarry JBJ,
pubmed-author:NimzEric LEL,
pubmed-author:PetrasCarol FCF,
pubmed-author:RafkaRobert JRJ,
pubmed-author:RastBrysonB,
pubmed-author:SakyaSubas MSM,
pubmed-author:SeibelScott BSB,
pubmed-author:ShavnyaAndreiA,
pubmed-author:SilviaAnnetteA,
pubmed-author:ZieglerCarl BCB
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pubmed:issnType |
Print
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pubmed:day |
5
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pubmed:volume |
14
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
95-8
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pubmed:dateRevised |
2005-11-17
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pubmed:meshHeading |
pubmed-meshheading:14684306-Administration, Oral,
pubmed-meshheading:14684306-Animals,
pubmed-meshheading:14684306-Cyclooxygenase 2,
pubmed-meshheading:14684306-Cyclooxygenase 2 Inhibitors,
pubmed-meshheading:14684306-Cyclooxygenase Inhibitors,
pubmed-meshheading:14684306-Dogs,
pubmed-meshheading:14684306-Isoenzymes,
pubmed-meshheading:14684306-Prostaglandin-Endoperoxide Synthases,
pubmed-meshheading:14684306-Pyridines,
pubmed-meshheading:14684306-Structure-Activity Relationship
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pubmed:year |
2004
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pubmed:articleTitle |
Discovery of a potent, selective and orally active canine COX-2 inhibitor, 2-(3-difluoromethyl-5-phenyl-pyrazol-1-yl)-5-methanesulfonyl-pyridine.
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pubmed:affiliation |
Veterinary Medicine Research and Development, Pfizer Inc., Groton, CT 06340, USA. jin_li@groton.pfizer.com
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pubmed:publicationType |
Journal Article
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