Linked Life Data

1468415

Source:http://linkedlifedata.com/resource/pubmed/id/1468415

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
1993-1-25
pubmed:abstractText
In 1991 a multicentre survey on the prevalence of metronidazole resistance in Helicobacter pylori in vitro was carried out in 12 hospitals in 11 different European countries. The susceptibility of Helicobacter pylori to metronidazole was determined in each centre by measuring the MIC on agar with the PDM E-test (AB Biodisk) according to a standard procedure. Overall, 122 of 443 (27.5%) strains tested were resistant to metronidazole (MIC > 8 micrograms/ml). The level of resistance to metronidazole varied markedly between centres (from 7% to 49%) and was found to be substantially higher in Africans and other non-Caucasian subjects than in natives from European countries. The overall rate of resistance to metronidazole was higher in females (34.7%) than in males (23.9%), and varied according to the age group, being highest among women aged 20 to 39 (50%). Previous use of metronidazole was reported in only 16 patients, 11 of whom (68.8%) harboured resistant Helicobacter pylori strains. Although differences in the rate of metronidazole resistance in Helicobacter pylori most probably relate to variations in use of this drug in different populations, such use may frequently go unrecognized. This study emphasises the importance of monitoring the drug resistance of Helicobacter pylori on a local basis. Standardisation of the methods for testing the susceptibility of Helicobacter pylori in vitro is clearly needed for this purpose.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0934-9723
pubmed:issnType
Print
pubmed:volume
11
pubmed:owner
NLM
pubmed:pagination
777-81
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
Results of a multicentre European survey in 1991 of metronidazole resistance in Helicobacter pylori. European Study Group on Antibiotic Susceptibility of Helicobacter pylori.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Multicenter Study