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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2004-5-10
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pubmed:abstractText |
Transdermal drug delivery has become an important means of drug administration. It presents numerous advantages but it is still limited by the small number of drugs with a suitable profile. The use of solvents that affect the skin barrier function is one of the classic strategies of penetration enhancement. Some of these solvents have well characterised actions on the stratum corneum, but the majority are still selected using empirical criteria. The objective of this work was to conduct a systematic study on the ability to affect skin permeation of solvents commonly used in transdermal formulations. An innovative methodology in this area was employed, consisting of the combination of skin surface biopsy with colorimetry.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/14680512-10425346,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14680512-10606787,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14680512-11337162,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14680512-11496961,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14680512-2023868,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14680512-5123329,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14680512-7638603,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14680512-7946377,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14680512-8075443,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14680512-8917826,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14680512-8987069,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14680512-9603659,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14680512-9687334,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14680512-9770437
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1471-5945
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
18
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pubmed:volume |
3
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:14680512-Administration, Cutaneous,
pubmed-meshheading:14680512-Adult,
pubmed-meshheading:14680512-Biopsy,
pubmed-meshheading:14680512-Female,
pubmed-meshheading:14680512-Humans,
pubmed-meshheading:14680512-Male,
pubmed-meshheading:14680512-Methylene Blue,
pubmed-meshheading:14680512-Permeability,
pubmed-meshheading:14680512-Pharmaceutical Vehicles,
pubmed-meshheading:14680512-Skin,
pubmed-meshheading:14680512-Skin Absorption,
pubmed-meshheading:14680512-Solvents
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pubmed:year |
2003
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pubmed:articleTitle |
Solvent effects in permeation assessed in vivo by skin surface biopsy.
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pubmed:affiliation |
Laboratório de Fisiologia Experimental & UCTF-Faculdade de Farmácia da Universidade de Lisboa, Av das Forças Armadas, 1600 Lisboa, Portugal. rosadocb@iol.pt
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Research Support, Non-U.S. Gov't
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