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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2003-12-17
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pubmed:abstractText |
The potential for bioterrorism involving smallpox has led to a debate about the durability of protective immunity against smallpox from vaccination. By assessing the T cell reactivity to vaccinia virus in a healthy population, we show that subjects who were vaccinated within the past 3 decades and who have a visible vaccination scar had remarkable T cell reactivity. However, person who were vaccinated within the past 3 decades but who do not have a scar and those who were vaccinated >4 decades ago had responses as low as those in unvaccinated subjects. Thus, we estimate that the significant T cell memory response to vaccinia virus from successful vaccination may persist for only 20-30 years. Furthermore, we found the vaccinia-specific cellular immunity could be easily assessed by determination of the frequencies of vaccinia-specific CD69 expression on T cell subsets. These data may help in the development of public health strategies to counter bioterrorism threats associated with smallpox.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1537-6591
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
38
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
86-9
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:14679452-Adolescent,
pubmed-meshheading:14679452-Adult,
pubmed-meshheading:14679452-Age Distribution,
pubmed-meshheading:14679452-Aged,
pubmed-meshheading:14679452-Antigens, CD,
pubmed-meshheading:14679452-Antigens, Differentiation, T-Lymphocyte,
pubmed-meshheading:14679452-Bioterrorism,
pubmed-meshheading:14679452-Child,
pubmed-meshheading:14679452-Child, Preschool,
pubmed-meshheading:14679452-Humans,
pubmed-meshheading:14679452-Immunity, Cellular,
pubmed-meshheading:14679452-Immunologic Memory,
pubmed-meshheading:14679452-Lectins, C-Type,
pubmed-meshheading:14679452-Lymphocyte Activation,
pubmed-meshheading:14679452-Middle Aged,
pubmed-meshheading:14679452-Population,
pubmed-meshheading:14679452-Smallpox Vaccine,
pubmed-meshheading:14679452-T-Lymphocyte Subsets,
pubmed-meshheading:14679452-T-Lymphocytes,
pubmed-meshheading:14679452-Vaccinia virus
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pubmed:year |
2004
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pubmed:articleTitle |
Age distribution for T cell reactivity to vaccinia virus in a healthy population.
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pubmed:affiliation |
Division of Infectious Diseases, Department of Internal Medicine, National Taiwan University Hospital and College of Medicine, National Taiwan University, Taipei, Taiwan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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