| pubmed-article:14679042 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:14679042 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:14679042 | lifeskim:mentions | umls-concept:C0019721 | lld:lifeskim |
| pubmed-article:14679042 | lifeskim:mentions | umls-concept:C1511790 | lld:lifeskim |
| pubmed-article:14679042 | lifeskim:mentions | umls-concept:C1332714 | lld:lifeskim |
| pubmed-article:14679042 | lifeskim:mentions | umls-concept:C0456387 | lld:lifeskim |
| pubmed-article:14679042 | pubmed:dateCreated | 2003-12-17 | lld:pubmed |
| pubmed-article:14679042 | pubmed:abstractText | The use of soluble class II MHC tetramers has enabled the identification of autoantigen-specific T cells in the peripheral blood of type 1 diabetes patients. Our approach takes advantage of the appearance of highly activated T cells expressing a CD25(+)/CD4(high+) phenotype induced by immobilized class II MHC monomer containing the GAD65 peptide. Almost all T cells that stain with the specific tetramer reside in this population and, since this activation profile is not present in normal subjects, it may provide a useful tool for analysis of the T cell response in autoimmune diabetes. The utilization of tetramer techniques in the detection of autoreactive T cells is a powerful tool to gain insight into mechanisms of the molecular basis of autoimmunity. The phenotyping of T cells should provide useful markers for progression of immune-mediated beta cell reactivity and can be utilized in clinical trials to evaluate the efficacy of the immunomodulatory therapies targeting intervention/prevention of autoimmune diseases. | lld:pubmed |
| pubmed-article:14679042 | pubmed:language | eng | lld:pubmed |
| pubmed-article:14679042 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14679042 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:14679042 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14679042 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14679042 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:14679042 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:14679042 | pubmed:issn | 0077-8923 | lld:pubmed |
| pubmed-article:14679042 | pubmed:author | pubmed-author:ReijonenHelen... | lld:pubmed |
| pubmed-article:14679042 | pubmed:author | pubmed-author:KwokWilliam... | lld:pubmed |
| pubmed-article:14679042 | pubmed:author | pubmed-author:NepomGerald... | lld:pubmed |
| pubmed-article:14679042 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:14679042 | pubmed:volume | 1005 | lld:pubmed |
| pubmed-article:14679042 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:14679042 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:14679042 | pubmed:pagination | 82-7 | lld:pubmed |
| pubmed-article:14679042 | pubmed:dateRevised | 2004-11-17 | lld:pubmed |
| pubmed-article:14679042 | pubmed:meshHeading | pubmed-meshheading:14679042... | lld:pubmed |
| pubmed-article:14679042 | pubmed:meshHeading | pubmed-meshheading:14679042... | lld:pubmed |
| pubmed-article:14679042 | pubmed:meshHeading | pubmed-meshheading:14679042... | lld:pubmed |
| pubmed-article:14679042 | pubmed:meshHeading | pubmed-meshheading:14679042... | lld:pubmed |
| pubmed-article:14679042 | pubmed:meshHeading | pubmed-meshheading:14679042... | lld:pubmed |
| pubmed-article:14679042 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:14679042 | pubmed:articleTitle | Detection of CD4+ autoreactive T cells in T1D using HLA class II tetramers. | lld:pubmed |
| pubmed-article:14679042 | pubmed:affiliation | Benaroya Research Institute at Virginia Mason, Seattle, Washington 98101, USA. reijonen@benaroyaresearch.org | lld:pubmed |
| pubmed-article:14679042 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14679042 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14679042 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14679042 | lld:pubmed |
