Source:http://linkedlifedata.com/resource/pubmed/id/14678452
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2003-12-17
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| pubmed:abstractText |
The purpose of the present paper was to investigate the relationship between the first exon at position +49 (A/G) polymorphism of the cytotoxic T lymphocyte antigen 4 (CTLA4) gene and bipolar disorder. Among the Korean patients diagnosed with bipolar disorder according to Diagnostic and Statistical Manual of Mental Disorders (4th edn; DSM-IV), 90 patients without serious medical illness, neurologic illness, hormonal disorder, or concomitant mental illness were selected. The normal control group consisted of 149 age- and sex-matched subjects without current or past history of autoimmune diseases or mental disorder. DNA was extracted from peripheral blood using proteinase K; and the exon 1 region of the CTLA4 gene was amplified by polymerase chain reaction. Gene typing was performed using single strand conformation polymorphism. There were no significant differences in genotype frequencies of CTLA4*G/G, CTLA4*G/A, and CTLA4*A/A between the patients with bipolar disorder and the control group (48.9% vs 46.3%, 44.4% vs 39.6%, and 6.7% vs 14.1%, respectively). There were no significant differences in allelic frequencies of CTLA4*G and CTLA4*A between the patients with bipolar disorder and the control group (71.1% vs 66.1%; 28.9% vs 33.9%, respectively). In the present study an association was not found of exon 1 (+49) polymorphism of CTLA4 gene with bipolar disorder in the Korean population.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation,
http://linkedlifedata.com/resource/pubmed/chemical/CTLA-4 Antigen,
http://linkedlifedata.com/resource/pubmed/chemical/CTLA4 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/DNA
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| pubmed:status |
MEDLINE
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| pubmed:month |
Feb
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| pubmed:issn |
1323-1316
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
58
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
21-4
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| pubmed:dateRevised |
2011-11-17
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| pubmed:meshHeading |
pubmed-meshheading:14678452-Adolescent,
pubmed-meshheading:14678452-Adult,
pubmed-meshheading:14678452-Aged,
pubmed-meshheading:14678452-Alleles,
pubmed-meshheading:14678452-Antigens, CD,
pubmed-meshheading:14678452-Antigens, Differentiation,
pubmed-meshheading:14678452-Bipolar Disorder,
pubmed-meshheading:14678452-CTLA-4 Antigen,
pubmed-meshheading:14678452-Case-Control Studies,
pubmed-meshheading:14678452-DNA,
pubmed-meshheading:14678452-Diagnostic and Statistical Manual of Mental Disorders,
pubmed-meshheading:14678452-Female,
pubmed-meshheading:14678452-Genotype,
pubmed-meshheading:14678452-Humans,
pubmed-meshheading:14678452-Korea,
pubmed-meshheading:14678452-Male,
pubmed-meshheading:14678452-Middle Aged,
pubmed-meshheading:14678452-Polymorphism, Genetic,
pubmed-meshheading:14678452-Polymorphism, Single-Stranded Conformational
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| pubmed:year |
2004
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| pubmed:articleTitle |
No evidence for an association of the CTLA4 gene with bipolar I disorder.
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| pubmed:affiliation |
Department of Psychiatry, College of Medicine, Catholic University of Korea, Seoul, Korea.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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