Linked Life Data

14676383

Source:http://linkedlifedata.com/resource/pubmed/id/14676383

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2003-12-16
pubmed:abstractText
In order to clarify the possible effects of high gravity environments on eggs and developing embryos, Rana rugosa and Xenopus laevis fertilized eggs and early embryos were raised in 2 G, 5 G, 7 G and 10 G up to the hatched tadpole stage. The results showed that: (1) High gravity significantly retarded the development of eggs and embryos beginning treatment before the blastula stage and induced various abnormalities, including two heads and microcephally suggesting that high gravity is apt to disrupt the animal-vegital axis. On the other hand, embryos beginning treatment after the gastrula stage showed a striking increase in the number of normal-appearing feeding tadpoles. (2) Autopsy revealed that brains, notochords and muscles were reduced in development and differentiation for embryos and tadpoles developed in high gravity. (3) It seems likely that the system for hydrogen peroxide detoxification develops abnormally in high gravity-treated embryos and tadpoles, which probably results in oxidative stress, leading to considerable cell damage.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
S
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0914-9201
pubmed:author
pubmed:issnType
Print
pubmed:volume
17
pubmed:owner
NASA
pubmed:authorsComplete
Y
pubmed:pagination
215-6
pubmed:dateRevised
2009-6-4
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
Effects of high gravity on amphibian development.
pubmed:affiliation
Institute for Amphibian Biology, Graduate School of Science, Hiroshima University, Higashihiroshima.
pubmed:publicationType
Journal Article, Comparative Study