|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
16 Pt 1
|
|
pubmed:dateCreated |
2003-12-16
|
|
pubmed:abstractText |
Heparanase-1 (HPR1) is an endoglycosidase that degrades the side chains of heparan sulfate proteoglycan (HSPG), a key component in cell surfaces, the extracellular matrix (ECM), and the basement membrane (BM). The purpose of this study was to evaluate HPR1 expression in thyroid neoplasms and its effect in degrading the HSPG substrates in the ECM and BM and to determine its role in thyroid tumor metastasis.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Dec
|
|
pubmed:issn |
1078-0432
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
1
|
|
pubmed:volume |
9
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
5968-79
|
|
pubmed:dateRevised |
2007-11-14
|
|
pubmed:meshHeading |
pubmed-meshheading:14676122-Adenoma,
pubmed-meshheading:14676122-Adolescent,
pubmed-meshheading:14676122-Adult,
pubmed-meshheading:14676122-Carcinoma, Medullary,
pubmed-meshheading:14676122-Carcinoma, Papillary,
pubmed-meshheading:14676122-DNA Probes,
pubmed-meshheading:14676122-Female,
pubmed-meshheading:14676122-Glucuronidase,
pubmed-meshheading:14676122-Heparan Sulfate Proteoglycans,
pubmed-meshheading:14676122-Humans,
pubmed-meshheading:14676122-Immunoenzyme Techniques,
pubmed-meshheading:14676122-In Situ Hybridization,
pubmed-meshheading:14676122-Male,
pubmed-meshheading:14676122-RNA, Messenger,
pubmed-meshheading:14676122-RNA, Neoplasm,
pubmed-meshheading:14676122-Thyroid Neoplasms,
pubmed-meshheading:14676122-Tumor Cells, Cultured
|
|
pubmed:year |
2003
|
|
pubmed:articleTitle |
Inverse correlation between heparan sulfate composition and heparanase-1 gene expression in thyroid papillary carcinomas: a potential role in tumor metastasis.
|
|
pubmed:affiliation |
Department of General Surgery, Rush University Medical Center, Chicago, Illinois 60612, USA. xxu@rush.edu
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
