| pubmed-article:14675602 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:14675602 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:14675602 | lifeskim:mentions | umls-concept:C0205474 | lld:lifeskim |
| pubmed-article:14675602 | lifeskim:mentions | umls-concept:C0004358 | lld:lifeskim |
| pubmed-article:14675602 | lifeskim:mentions | umls-concept:C0393639 | lld:lifeskim |
| pubmed-article:14675602 | lifeskim:mentions | umls-concept:C1441616 | lld:lifeskim |
| pubmed-article:14675602 | lifeskim:mentions | umls-concept:C0936012 | lld:lifeskim |
| pubmed-article:14675602 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:14675602 | pubmed:dateCreated | 2003-12-16 | lld:pubmed |
| pubmed-article:14675602 | pubmed:abstractText | Hashimoto's encephalopathy (HE) is thought to be caused by disorders of immune mechanisms. Although immunologically mediated central nervous system vasculitis or unidentified anti-neuronal autoantibodies have been suspected of causing HE, its pathogenesis is still unclear. For the study presented here, two patients with typical clinical and laboratory/electrophysiological findings of HE were analyzed to clarify the role of anti-neuronal autoantibodies in the pathogenesis of HE. The autopsied brain of one of the patients was histopathologically examined. For Western blotting analysis and immunohistochemistry, serum and purified immunoglobulin G obtained from the other patient were used. Autopsy revealed no evidence of central nervous system vasculitis or other abnormal findings in the brain. The patient's serum contained an anti-neuronal autoantibody that immunohistochemically labeled neurons of mouse and human cerebral cortices and reacted with the 36-kDa antigenic protein present in a soluble fraction obtained from human cerebral cortex. Our results indicate that anti-neuronal autoantibodies may be associated with the pathogenesis of HE. | lld:pubmed |
| pubmed-article:14675602 | pubmed:language | eng | lld:pubmed |
| pubmed-article:14675602 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14675602 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:14675602 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14675602 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14675602 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:14675602 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:14675602 | pubmed:issn | 0022-510X | lld:pubmed |
| pubmed-article:14675602 | pubmed:author | pubmed-author:HashimotoTaka... | lld:pubmed |
| pubmed-article:14675602 | pubmed:author | pubmed-author:YazakiMasahid... | lld:pubmed |
| pubmed-article:14675602 | pubmed:author | pubmed-author:IkedaShu-ichi... | lld:pubmed |
| pubmed-article:14675602 | pubmed:author | pubmed-author:TokudaTakahik... | lld:pubmed |
| pubmed-article:14675602 | pubmed:author | pubmed-author:OharaShinjiS | lld:pubmed |
| pubmed-article:14675602 | pubmed:author | pubmed-author:OideTakashiT | lld:pubmed |
| pubmed-article:14675602 | pubmed:author | pubmed-author:KanekoKazumaK | lld:pubmed |
| pubmed-article:14675602 | pubmed:author | pubmed-author:WataraiMegumi... | lld:pubmed |
| pubmed-article:14675602 | pubmed:author | pubmed-author:MitsuhashiShi... | lld:pubmed |
| pubmed-article:14675602 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:14675602 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:14675602 | pubmed:volume | 217 | lld:pubmed |
| pubmed-article:14675602 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:14675602 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:14675602 | pubmed:pagination | 7-12 | lld:pubmed |
| pubmed-article:14675602 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:14675602 | pubmed:meshHeading | pubmed-meshheading:14675602... | lld:pubmed |
| pubmed-article:14675602 | pubmed:meshHeading | pubmed-meshheading:14675602... | lld:pubmed |
| pubmed-article:14675602 | pubmed:meshHeading | pubmed-meshheading:14675602... | lld:pubmed |
| pubmed-article:14675602 | pubmed:meshHeading | pubmed-meshheading:14675602... | lld:pubmed |
| pubmed-article:14675602 | pubmed:meshHeading | pubmed-meshheading:14675602... | lld:pubmed |
| pubmed-article:14675602 | pubmed:meshHeading | pubmed-meshheading:14675602... | lld:pubmed |
| pubmed-article:14675602 | pubmed:meshHeading | pubmed-meshheading:14675602... | lld:pubmed |
| pubmed-article:14675602 | pubmed:meshHeading | pubmed-meshheading:14675602... | lld:pubmed |
| pubmed-article:14675602 | pubmed:meshHeading | pubmed-meshheading:14675602... | lld:pubmed |
| pubmed-article:14675602 | pubmed:meshHeading | pubmed-meshheading:14675602... | lld:pubmed |
| pubmed-article:14675602 | pubmed:meshHeading | pubmed-meshheading:14675602... | lld:pubmed |
| pubmed-article:14675602 | pubmed:meshHeading | pubmed-meshheading:14675602... | lld:pubmed |
| pubmed-article:14675602 | pubmed:meshHeading | pubmed-meshheading:14675602... | lld:pubmed |
| pubmed-article:14675602 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:14675602 | pubmed:articleTitle | Anti-neuronal autoantibody in Hashimoto's encephalopathy: neuropathological, immunohistochemical, and biochemical analysis of two patients. | lld:pubmed |
| pubmed-article:14675602 | pubmed:affiliation | Third Department of Medicine, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto 390-8621, Japan. | lld:pubmed |
| pubmed-article:14675602 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:14675602 | pubmed:publicationType | Comparative Study | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14675602 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14675602 | lld:pubmed |
