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pubmed-article:14674694pubmed:abstractTextHuman Aurora/Ipl1-related kinase 2 (Aurora-B) is a key regulator of mitosis. Here human proteasome alpha-subunit C8 (HC8) was identified to interact with the Aurora-B by yeast two-hybrid screen. This finding was confirmed by GST pull-down assays and immunoprecipitation experiments. The Aurora-B protein level increased in HeLa cells cultured with proteasome inhibitor ALLN. Our data suggest that Aurora-B might undergo degradation by binding to HC8 in a proteasome-dependent manner during mitosis.lld:pubmed
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pubmed-article:14674694pubmed:articleTitleHuman aurora-B binds to a proteasome alpha-subunit HC8 and undergoes degradation in a proteasome-dependent manner.lld:pubmed
pubmed-article:14674694pubmed:affiliationState Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Science, Fudan University, Shanghai, PR China.lld:pubmed
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pubmed-article:14674694pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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