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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2003-12-15
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pubmed:abstractText |
Prostate cancer (PC) has a propensity to metastasize to the skeleton, inducing an osteoblastic response in the host. Recent epidemiological studies have suggested that circulating IGF-I may be important for both the pathogenesis and dissemination of PC. We have postulated that tumor secreted IGF-I in conjunction with endogenous IGF-I contributes to the osteoblastic phenotype characteristic of metastatic PC.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Culture Media, Conditioned,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin-Like Growth Factor Binding...,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin-Like Growth Factor I,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/RANK Ligand,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Ribosomal, 18S,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor Activator of Nuclear...,
http://linkedlifedata.com/resource/pubmed/chemical/TNFRSF11A protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/TNFSF11 protein, human
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0270-4137
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2003 Wiley-Liss, Inc.
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
58
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
41-9
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:14673951-Bone Neoplasms,
pubmed-meshheading:14673951-Carrier Proteins,
pubmed-meshheading:14673951-Cell Line, Tumor,
pubmed-meshheading:14673951-Culture Media, Conditioned,
pubmed-meshheading:14673951-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:14673951-Humans,
pubmed-meshheading:14673951-Insulin-Like Growth Factor Binding Proteins,
pubmed-meshheading:14673951-Insulin-Like Growth Factor I,
pubmed-meshheading:14673951-Male,
pubmed-meshheading:14673951-Membrane Glycoproteins,
pubmed-meshheading:14673951-Prostatic Neoplasms,
pubmed-meshheading:14673951-RANK Ligand,
pubmed-meshheading:14673951-RNA, Messenger,
pubmed-meshheading:14673951-RNA, Ribosomal, 18S,
pubmed-meshheading:14673951-Receptor Activator of Nuclear Factor-kappa B,
pubmed-meshheading:14673951-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:14673951-Up-Regulation
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pubmed:year |
2004
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pubmed:articleTitle |
Prostate carcinoma cells that have resided in bone have an upregulated IGF-I axis.
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pubmed:affiliation |
Department of Medicine, VAMC and Emory University, Atlanta, Georgia 30033, USA. jrubin02@emory.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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