Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2003-12-30
pubmed:abstractText
Recently, it has been reported that Na+/H+ exchanger (NHE) inhibitors demonstrated protective effects on ischemia/reperfusion brain injury in animal models. However, the mechanisms by which the neurons were protected against ischemic insult remain unclear. To reveal the cellular mechanism of the NHE inhibitor on the neuronal death, we examined the effects of a selective NHE inhibitor, SM-20220 (N-[aminoiminomethyl]-1-methyl-1H-indole-2-carboxamide methanesulfonate), on glutamate-induced neuronal death in rat cortical culture.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
1524-4628
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
35
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
185-90
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:14671239-Amides, pubmed-meshheading:14671239-Animals, pubmed-meshheading:14671239-Calcium, pubmed-meshheading:14671239-Cell Death, pubmed-meshheading:14671239-Cells, Cultured, pubmed-meshheading:14671239-Cerebral Cortex, pubmed-meshheading:14671239-Dose-Response Relationship, Drug, pubmed-meshheading:14671239-Excitatory Amino Acid Antagonists, pubmed-meshheading:14671239-Glutamic Acid, pubmed-meshheading:14671239-Hydrogen-Ion Concentration, pubmed-meshheading:14671239-Indoles, pubmed-meshheading:14671239-Intracellular Fluid, pubmed-meshheading:14671239-Neurons, pubmed-meshheading:14671239-Neuroprotective Agents, pubmed-meshheading:14671239-Neurotoxins, pubmed-meshheading:14671239-Rats, pubmed-meshheading:14671239-Rats, Wistar, pubmed-meshheading:14671239-Sodium-Hydrogen Antiporter
pubmed:year
2004
pubmed:articleTitle
Na+/H+ exchanger inhibitor, SM-20220, is protective against excitotoxicity in cultured cortical neurons.
pubmed:affiliation
Department of Pharmacology, Hamamatsu University School of Medicine, Hamamatsu, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't