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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2004-3-15
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pubmed:abstractText |
The present study tested the hypothesis that there is impaired function of alpha(2)-adrenergic autoreceptors and increased transmitter release from sympathetic nerves associated with mesenteric arteries and veins from DOCA-salt rats. High-performance liquid chromatography was used to measure the overflow of ATP and norepinephrine (NE) from electrically stimulated mesenteric artery and vein preparations in vitro. In sham arteries, nerve stimulation evoked a 1.5-fold increase in NE release, whereas in DOCA-salt arteries there was a 3.9-fold increase in NE release over basal levels (P < 0.05). In contrast, stimulated ATP release was not different in DOCA-salt arteries compared with sham arteries. In sham veins, nerve stimulation evoked a 2.9-fold increase in NE release, whereas in DOCA-salt veins there was a 8.4-fold increase in NE release over basal levels (P < 0.05). In sham rats NE release, normalized to basal levels, was greater in veins than in arteries (P < 0.05). The alpha(2)-adrenergic receptor antagonist yohimbine (1 microM) increased ATP and NE release in sham but not DOCA-salt arteries. The alpha(2)-adrenergic receptor agonist UK-14304 (10 microM) decreased ATP release in sham but not DOCA-salt arteries. In sham veins, UK-14304 decreased, but yohimbine increased, NE release; effects that were not observed in DOCA-salt veins. These data show that nerve stimulation causes a greater increase in NE release from nerves associated with veins compared with arteries. In addition, impairment of alpha(2)-adrenergic autoreceptor function in sympathetic nerves associated with arteries and veins from DOCA-salt rats results in increased NE release.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adenine Nucleotides,
http://linkedlifedata.com/resource/pubmed/chemical/Adenosine,
http://linkedlifedata.com/resource/pubmed/chemical/Adenosine Triphosphate,
http://linkedlifedata.com/resource/pubmed/chemical/Adrenergic alpha-2 Receptor Agonists,
http://linkedlifedata.com/resource/pubmed/chemical/Adrenergic alpha-2 Receptor...,
http://linkedlifedata.com/resource/pubmed/chemical/Adrenergic alpha-Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Autoreceptors,
http://linkedlifedata.com/resource/pubmed/chemical/Desoxycorticosterone,
http://linkedlifedata.com/resource/pubmed/chemical/Norepinephrine,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Adrenergic, alpha-2,
http://linkedlifedata.com/resource/pubmed/chemical/Sodium Chloride
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0363-6135
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
286
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
H1558-64
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:14670814-Adenine Nucleotides,
pubmed-meshheading:14670814-Adenosine,
pubmed-meshheading:14670814-Adenosine Triphosphate,
pubmed-meshheading:14670814-Adrenergic alpha-2 Receptor Agonists,
pubmed-meshheading:14670814-Adrenergic alpha-2 Receptor Antagonists,
pubmed-meshheading:14670814-Adrenergic alpha-Antagonists,
pubmed-meshheading:14670814-Animals,
pubmed-meshheading:14670814-Autoreceptors,
pubmed-meshheading:14670814-Chromatography, High Pressure Liquid,
pubmed-meshheading:14670814-Desoxycorticosterone,
pubmed-meshheading:14670814-Electric Stimulation,
pubmed-meshheading:14670814-Electrochemistry,
pubmed-meshheading:14670814-Hypertension,
pubmed-meshheading:14670814-Mesenteric Arteries,
pubmed-meshheading:14670814-Mesenteric Veins,
pubmed-meshheading:14670814-Muscle Tonus,
pubmed-meshheading:14670814-Norepinephrine,
pubmed-meshheading:14670814-Rats,
pubmed-meshheading:14670814-Rats, Sprague-Dawley,
pubmed-meshheading:14670814-Receptors, Adrenergic, alpha-2,
pubmed-meshheading:14670814-Sodium Chloride,
pubmed-meshheading:14670814-Spectrometry, Fluorescence,
pubmed-meshheading:14670814-Sympathetic Nervous System
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pubmed:year |
2004
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pubmed:articleTitle |
Impaired function of alpha2-adrenergic autoreceptors on sympathetic nerves associated with mesenteric arteries and veins in DOCA-salt hypertension.
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pubmed:affiliation |
Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI 48824, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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