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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-2
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pubmed:dateCreated |
2004-4-14
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pubmed:abstractText |
Experimental evidence from animal studies suggests reciprocal functional interactions between endogenous brain cannabinoid and opioid systems. There is recent evidence for a role of the opioid system in the modulation of the reinforcing effects of synthetic cannabinoid CB1 receptor agonists in rodents. Since Delta(9)-tetrahydrocannabinol (THC), the natural psychoactive ingredient in marijuana, is actively and persistently self-administered by squirrel monkeys, this provides an opportunity to directly study involvement of opioid systems in the reinforcing effects of THC in non-human primates.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0033-3158
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
173
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
186-94
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:14668977-Analgesics, Non-Narcotic,
pubmed-meshheading:14668977-Anesthetics, Local,
pubmed-meshheading:14668977-Animals,
pubmed-meshheading:14668977-Behavior, Animal,
pubmed-meshheading:14668977-Cocaine,
pubmed-meshheading:14668977-Conditioning, Operant,
pubmed-meshheading:14668977-Dose-Response Relationship, Drug,
pubmed-meshheading:14668977-Drug Interactions,
pubmed-meshheading:14668977-Male,
pubmed-meshheading:14668977-Naltrexone,
pubmed-meshheading:14668977-Narcotic Antagonists,
pubmed-meshheading:14668977-Reinforcement (Psychology),
pubmed-meshheading:14668977-Reinforcement Schedule,
pubmed-meshheading:14668977-Saimiri,
pubmed-meshheading:14668977-Self Administration,
pubmed-meshheading:14668977-Tetrahydrocannabinol
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pubmed:year |
2004
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pubmed:articleTitle |
The opioid antagonist naltrexone reduces the reinforcing effects of Delta 9 tetrahydrocannabinol (THC) in squirrel monkeys.
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pubmed:affiliation |
Preclinical Pharmacology Section, Behavioral Neuroscience Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, MD 21224, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.
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