Linked Life Data

14668705

Source:http://linkedlifedata.com/resource/pubmed/id/14668705

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2003-12-11
pubmed:abstractText
Several investigations have discovered important physiologic links in the development of contrast-induced nephropathy (CIN). Studies using a canine kidney model showed that contrast media produce a direct cytotoxic effect on the renal structures. Also, there is increasing evidence that apoptosis is involved in CIN as a result of cell injury. It has been suggested that hemodynamic changes resulting from administration of contrast media may contribute to the development of CIN, although the data are not conclusive. Several vasoactive substances, such as endothelin, prostaglandins, nitric oxide, and adenosine, have been implicated in the pathogenesis of CIN, as have immune mechanisms. Several factors contribute to the development of CIN, including preexisting renal insufficiency, older age, diabetes mellitus, reduced left ventricular systolic function, advanced heart failure, acute myocardial infarction, and shock. The authors also present the risk score they developed to help clinicians identify patients with different responses to contrast exposure.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1530-6550
pubmed:author
pubmed:issnType
Print
pubmed:volume
4 Suppl 5
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
S10-8
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
Understanding the consequences of contrast-induced nephropathy.
pubmed:affiliation
Cardiovascular Research Foundation, Lenox Hill Heart and Vascular Institute, New York, New York, USA.
pubmed:publicationType
Journal Article, Review