Source:http://linkedlifedata.com/resource/pubmed/id/14667581
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
2003-12-11
|
| pubmed:abstractText |
To search for gene expression changes probably responsible for deafferentation-induced reorganization in the brain, we have analyzed the expression of mRNAs for ephrin-A1, -A2, -A3, -A5 and -B1 in the rat hippocampus following transection of the entorhinal afferents by semi-quantitative reverse transcription polymerase chain reaction (RT-PCR). We found that their expression in the deafferented hippocampus increased significantly by 7 days, reached the maximum at 14 days and almost recovered to control levels by 60 days post-lesion. It is notable that the up-regulation of ephrin mRNAs occurs during the reorganization in the deafferented hippocampus, suggesting that ephrins may be involved in the plasticity events of the adult brain after lesion.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
0169-328X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
12
|
| pubmed:volume |
120
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
79-83
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:14667581-Analysis of Variance,
pubmed-meshheading:14667581-Animals,
pubmed-meshheading:14667581-Blotting, Northern,
pubmed-meshheading:14667581-Causalgia,
pubmed-meshheading:14667581-Denervation,
pubmed-meshheading:14667581-Ephrins,
pubmed-meshheading:14667581-Female,
pubmed-meshheading:14667581-Functional Laterality,
pubmed-meshheading:14667581-Gene Expression Regulation,
pubmed-meshheading:14667581-Hippocampus,
pubmed-meshheading:14667581-In Situ Hybridization,
pubmed-meshheading:14667581-Neuronal Plasticity,
pubmed-meshheading:14667581-Perforant Pathway,
pubmed-meshheading:14667581-RNA, Messenger,
pubmed-meshheading:14667581-Rats,
pubmed-meshheading:14667581-Rats, Sprague-Dawley,
pubmed-meshheading:14667581-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:14667581-Semaphorin-3A,
pubmed-meshheading:14667581-Time Factors
|
| pubmed:year |
2003
|
| pubmed:articleTitle |
Semi-quantitative expression analysis of ephrin mRNAs in the deafferented hippocampus.
|
| pubmed:affiliation |
Key Laboratory of Neurobiology, Shanghai Institute of Physiology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031, PR China.
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|