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| pubmed-article:14667507 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:14667507 | lifeskim:mentions | umls-concept:C1416924 | lld:lifeskim |
| pubmed-article:14667507 | lifeskim:mentions | umls-concept:C1425011 | lld:lifeskim |
| pubmed-article:14667507 | lifeskim:mentions | umls-concept:C1314939 | lld:lifeskim |
| pubmed-article:14667507 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:14667507 | pubmed:dateCreated | 2003-12-11 | lld:pubmed |
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| pubmed-article:14667507 | pubmed:abstractText | By positional cloning, we identified two breakpoint-spanning genes in a familial clear cell renal cell carcinoma (CCRCC)-associated t(1;3)(q32.1;q13.3): LSAMP and NORE1 (RASSF1 homolog). Both genes are downregulated in 9 of 9 RCC cell lines. While the NORE1A promoter predominantly presents partial methylation in 6 of the cell lines and 17/53 (32%) primary tumors, the LSAMP promoter is completely methylated in 5 of 9 cell lines and in 14/53 (26%) sporadic and 4 familial CCRCCs. Expression of LSAMP and NORE1A proteins in CCRCC cell lines inhibited cell proliferation. These characteristics indicate that LSAMP and NORE1A may represent new candidate tumor suppressors for CCRCC. | lld:pubmed |
| pubmed-article:14667507 | pubmed:language | eng | lld:pubmed |
| pubmed-article:14667507 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14667507 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:14667507 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:14667507 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:14667507 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:14667507 | pubmed:issn | 1535-6108 | lld:pubmed |
| pubmed-article:14667507 | pubmed:author | pubmed-author:TakahashiMasa... | lld:pubmed |
| pubmed-article:14667507 | pubmed:author | pubmed-author:LarssonCathar... | lld:pubmed |
| pubmed-article:14667507 | pubmed:author | pubmed-author:ZhangChunC | lld:pubmed |
| pubmed-article:14667507 | pubmed:author | pubmed-author:ChenJindongJ | lld:pubmed |
| pubmed-article:14667507 | pubmed:author | pubmed-author:TehBin TeanBT | lld:pubmed |
| pubmed-article:14667507 | pubmed:author | pubmed-author:KagawaSusumuS | lld:pubmed |
| pubmed-article:14667507 | pubmed:author | pubmed-author:SchoumansJacq... | lld:pubmed |
| pubmed-article:14667507 | pubmed:author | pubmed-author:KhooSok... | lld:pubmed |
| pubmed-article:14667507 | pubmed:author | pubmed-author:KanayamaHiro-... | lld:pubmed |
| pubmed-article:14667507 | pubmed:author | pubmed-author:MaherEamonn... | lld:pubmed |
| pubmed-article:14667507 | pubmed:author | pubmed-author:LuiWeng-OnnWO | lld:pubmed |
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| pubmed-article:14667507 | pubmed:author | pubmed-author:ClarkGeoffrey... | lld:pubmed |
| pubmed-article:14667507 | pubmed:author | pubmed-author:AlbertsArthur... | lld:pubmed |
| pubmed-article:14667507 | pubmed:author | pubmed-author:SugimuraJunJ | lld:pubmed |
| pubmed-article:14667507 | pubmed:author | pubmed-author:PetilloDavidD | lld:pubmed |
| pubmed-article:14667507 | pubmed:author | pubmed-author:AstutiDewiD | lld:pubmed |
| pubmed-article:14667507 | pubmed:author | pubmed-author:LaveryToddT | lld:pubmed |
| pubmed-article:14667507 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:14667507 | pubmed:volume | 4 | lld:pubmed |
| pubmed-article:14667507 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:14667507 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:14667507 | pubmed:pagination | 405-13 | lld:pubmed |
| pubmed-article:14667507 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:14667507 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:14667507 | pubmed:articleTitle | The t(1;3) breakpoint-spanning genes LSAMP and NORE1 are involved in clear cell renal cell carcinomas. | lld:pubmed |
| pubmed-article:14667507 | pubmed:affiliation | Lab of Cancer Genetics, Van Andel Research Institute, Grand Rapids, MI 49503, USA. | lld:pubmed |
| pubmed-article:14667507 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:14667507 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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