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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2003-12-11
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pubmed:databankReference |
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pubmed:abstractText |
By positional cloning, we identified two breakpoint-spanning genes in a familial clear cell renal cell carcinoma (CCRCC)-associated t(1;3)(q32.1;q13.3): LSAMP and NORE1 (RASSF1 homolog). Both genes are downregulated in 9 of 9 RCC cell lines. While the NORE1A promoter predominantly presents partial methylation in 6 of the cell lines and 17/53 (32%) primary tumors, the LSAMP promoter is completely methylated in 5 of 9 cell lines and in 14/53 (26%) sporadic and 4 familial CCRCCs. Expression of LSAMP and NORE1A proteins in CCRCC cell lines inhibited cell proliferation. These characteristics indicate that LSAMP and NORE1A may represent new candidate tumor suppressors for CCRCC.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1535-6108
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pubmed:author |
pubmed-author:AlbertsArthur SAS,
pubmed-author:AstutiDewiD,
pubmed-author:ChenJindongJ,
pubmed-author:ClarkGeoffrey JGJ,
pubmed-author:KagawaSusumuS,
pubmed-author:KanayamaHiro-omiHO,
pubmed-author:KhooSok KeanSK,
pubmed-author:LarssonCatharinaC,
pubmed-author:LaveryToddT,
pubmed-author:LuiWeng-OnnWO,
pubmed-author:MaherEamonn RER,
pubmed-author:PetilloDavidD,
pubmed-author:SchoumansJacquelineJ,
pubmed-author:SugimuraJunJ,
pubmed-author:TakahashiMasayukiM,
pubmed-author:TehBin TeanBT,
pubmed-author:VosMichele DMD,
pubmed-author:ZhangChunC
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pubmed:issnType |
Print
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pubmed:volume |
4
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
405-13
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:14667507-Adenocarcinoma, Clear Cell,
pubmed-meshheading:14667507-Animals,
pubmed-meshheading:14667507-Base Sequence,
pubmed-meshheading:14667507-Carcinoma, Renal Cell,
pubmed-meshheading:14667507-Cell Adhesion Molecules, Neuronal,
pubmed-meshheading:14667507-Cell Division,
pubmed-meshheading:14667507-Cells, Cultured,
pubmed-meshheading:14667507-Cloning, Molecular,
pubmed-meshheading:14667507-DNA Methylation,
pubmed-meshheading:14667507-GPI-Linked Proteins,
pubmed-meshheading:14667507-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:14667507-Humans,
pubmed-meshheading:14667507-Molecular Sequence Data,
pubmed-meshheading:14667507-Monomeric GTP-Binding Proteins
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pubmed:year |
2003
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pubmed:articleTitle |
The t(1;3) breakpoint-spanning genes LSAMP and NORE1 are involved in clear cell renal cell carcinomas.
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pubmed:affiliation |
Lab of Cancer Genetics, Van Andel Research Institute, Grand Rapids, MI 49503, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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