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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2003-12-11
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pubmed:abstractText |
Liquid chromatography in combination with mass spectrometry (LC-MS) is key to the identification of metabolites in new molecular imaging probes. These metabolites can be generated using hepatocytes from various species in vitro. Metabolites produced from 4-fluoro-N-[2-[4-(2-methoxylphenyl)piperazino]ethyl]-N-(2-pyridyl)cyclohexane carboxamide (FCWAY) using rat and human hepatocytes are different, whereas metabolites from (3-(3-fluoropropylthio)-1,2,5-thiadiazol-4-yl)-tetrahydro-l-methyl-pyridine (FP-TZTP) using rat and human hepatocytes were similar. The combination of LC-MS and hepatocytes are an indispensable tool in the development of new molecular imaging probes.
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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pubmed:issn |
1536-1632
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:volume |
5
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
397-403
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:14667494-Animals,
pubmed-meshheading:14667494-Chromatography, Liquid,
pubmed-meshheading:14667494-Fluorine Radioisotopes,
pubmed-meshheading:14667494-Hepatocytes,
pubmed-meshheading:14667494-Humans,
pubmed-meshheading:14667494-Male,
pubmed-meshheading:14667494-Mass Spectrometry,
pubmed-meshheading:14667494-Molecular Structure,
pubmed-meshheading:14667494-Piperazines,
pubmed-meshheading:14667494-Pyridines,
pubmed-meshheading:14667494-Radiopharmaceuticals,
pubmed-meshheading:14667494-Rats,
pubmed-meshheading:14667494-Rats, Sprague-Dawley,
pubmed-meshheading:14667494-Thiazoles
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pubmed:articleTitle |
Application of LC-MS to the analysis of new radiopharmaceuticals.
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pubmed:affiliation |
PET Department, Warren G. Magnuson Clinical Center, NIH, Bethesda, MD 20892, USA.
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pubmed:publicationType |
Journal Article,
In Vitro
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