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pubmed-article:14667379pubmed:dateCreated2003-12-11lld:pubmed
pubmed-article:14667379pubmed:abstractTextEvolutionary theories of senescence postulate that lifespan is determined by the age-dependent decrease in the effects of natural selection. Factors that influence survival and reproduction at early life stages have a larger impact on fitness than factors that influence later life stages. According to these views, selection for rapid sexual maturation and a steep age-dependent decrease in fitness drive the evolution of short lifespans. Here, we report on the survival trajectory of Nothobranchius furzeri (Pisces: Ciprinodontidae): a member of a group of annual species found in temporary bodies of water whose life expectancy in the wild is limited to a few months. We find that maximum survival of N. furzeri in the laboratory is less than 12 weeks. The temporal trajectory of survival shows an age-dependent increase in the mortality rate that is typical of organisms with defined lifespans. The lifespan of N. furzeri is exceptionally short for a vertebrate: owing to its small size and the possibility of propagation in captivity, N. furzeri could be used as a convenient model for ageing research.lld:pubmed
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pubmed-article:14667379pubmed:monthNovlld:pubmed
pubmed-article:14667379pubmed:issn0962-8452lld:pubmed
pubmed-article:14667379pubmed:authorpubmed-author:CellerinoAles...lld:pubmed
pubmed-article:14667379pubmed:authorpubmed-author:ValdesaliciSt...lld:pubmed
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pubmed-article:14667379pubmed:day7lld:pubmed
pubmed-article:14667379pubmed:volume270 Suppl 2lld:pubmed
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pubmed-article:14667379pubmed:paginationS189-91lld:pubmed
pubmed-article:14667379pubmed:dateRevised2009-11-18lld:pubmed
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pubmed-article:14667379pubmed:year2003lld:pubmed
pubmed-article:14667379pubmed:articleTitleExtremely short lifespan in the annual fish Nothobranchius furzeri.lld:pubmed
pubmed-article:14667379pubmed:affiliationAssociazione Italiana Killifish, Canossa 42026, Italy.lld:pubmed
pubmed-article:14667379pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:14667379pubmed:publicationTypeComparative Studylld:pubmed
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