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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
26
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pubmed:dateCreated |
2003-12-11
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pubmed:abstractText |
The metabolically stabilized LPA analogue, 1-oleoyl-2-O-methyl-rac-glycerophosphothioate (OMPT), is a potent agonist for the LPA(3) G-protein-coupled receptor. A new enantiospecific synthesis of both (2R)-OMPT and (2S)-OMPT is described. Calcium release assays in both LPA(3)-transfected insect Sf9 and rat hepatoma Rh7777 cells showed that (2S)-OMPT was 5- to 20-fold more active than (2R)-OMPT. Similar results were found for calcium release, MAPK and Akt activation, and IL-6 release in human OVCAR3 ovarian cancer cells.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/AKT1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Akt1 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-6,
http://linkedlifedata.com/resource/pubmed/chemical/Lysophospholipids,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase...,
http://linkedlifedata.com/resource/pubmed/chemical/Organothiophosphorus Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphatidic Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-akt,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, G-Protein-Coupled,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Lysophosphatidic Acid
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0022-2623
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
18
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pubmed:volume |
46
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5575-8
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:14667211-Animals,
pubmed-meshheading:14667211-Calcium,
pubmed-meshheading:14667211-Cell Line,
pubmed-meshheading:14667211-Cell Line, Tumor,
pubmed-meshheading:14667211-Enzyme Activation,
pubmed-meshheading:14667211-Humans,
pubmed-meshheading:14667211-Interleukin-6,
pubmed-meshheading:14667211-Lysophospholipids,
pubmed-meshheading:14667211-Mitogen-Activated Protein Kinase Kinases,
pubmed-meshheading:14667211-Organothiophosphorus Compounds,
pubmed-meshheading:14667211-Phosphatidic Acids,
pubmed-meshheading:14667211-Phosphorylation,
pubmed-meshheading:14667211-Protein-Serine-Threonine Kinases,
pubmed-meshheading:14667211-Proto-Oncogene Proteins,
pubmed-meshheading:14667211-Proto-Oncogene Proteins c-akt,
pubmed-meshheading:14667211-Rats,
pubmed-meshheading:14667211-Receptors, G-Protein-Coupled,
pubmed-meshheading:14667211-Receptors, Lysophosphatidic Acid,
pubmed-meshheading:14667211-Stereoisomerism,
pubmed-meshheading:14667211-Structure-Activity Relationship
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pubmed:year |
2003
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pubmed:articleTitle |
Enantioselective responses to a phosphorothioate analogue of lysophosphatidic acid with LPA3 receptor-selective agonist activity.
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pubmed:affiliation |
Department of Medicinal Chemistry, The University of Utah, 419 Wakara Way, Suite 205, Salt Lake City, UT 84108, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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