Linked Life Data

14666735

Source:http://linkedlifedata.com/resource/pubmed/id/14666735

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6a
pubmed:dateCreated
2003-12-11
pubmed:abstractText
Mannan-binding protein (MBP) is a C-type lectin, which binds to carbohydrates on the surface of some microorganisms and kills them through the activation of complement. This complement activation pathway is called the lectin pathway. MBP also kills mammalian cells that express MBP ligands on their surfaces via the lectin pathway. Recently, we found anti-tumor activity of MBP in vivo using tumor cells transplanted into nude mice. We propose to call this anti-tumor effect mannan-binding protein-dependent cell-mediated cytotoxicity (MDCC), because it does not require complement activation, and the involvement of some immune cells was assumed. Very recently, MBP was demonstrated to be selectively expressed in epithelial cells of the small intestine. This finding may suggest that MBP plays an important role in the small intestine as a host defense factor.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0250-7005
pubmed:author
pubmed:issnType
Print
pubmed:volume
23
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
4467-71
pubmed:dateRevised
2005-11-16
pubmed:meshHeading
pubmed:articleTitle
Role of mannan-binding protein, MBP, in innate immunity.
pubmed:affiliation
Department of Biological Chemistry, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606-8501, Japan.
pubmed:publicationType
Journal Article, Review