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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5A
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pubmed:dateCreated |
2003-12-11
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pubmed:abstractText |
During recent decades, studies of various cancer-related genes has led to a growing understanding of molecular mechanisms of gastrointestinal cancer resulting in a genetic progression model. Nevertheless, with a few exceptions, our knowledge of participating genes has not been exploited for gene therapeutic approaches. Therefore, we monitored the promoter activity of genes shown to be significantly expressed in gastrointestinal tumors to select optimally active promoters for recombinant DNA constructs. Such molecules will contain a suicide gene under a suitable cell type-specific regulatory element.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Keratins,
http://linkedlifedata.com/resource/pubmed/chemical/Luciferases,
http://linkedlifedata.com/resource/pubmed/chemical/MUC2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Mucin-1,
http://linkedlifedata.com/resource/pubmed/chemical/Mucin-2,
http://linkedlifedata.com/resource/pubmed/chemical/Mucins,
http://linkedlifedata.com/resource/pubmed/chemical/Peptides,
http://linkedlifedata.com/resource/pubmed/chemical/Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/SEL1L protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/TFF1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Telomerase,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Proteins
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pubmed:status |
MEDLINE
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pubmed:issn |
0250-7005
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
23
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4011-5
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:14666711-Adenocarcinoma,
pubmed-meshheading:14666711-Cell Line, Tumor,
pubmed-meshheading:14666711-DNA-Binding Proteins,
pubmed-meshheading:14666711-Exons,
pubmed-meshheading:14666711-Gastrointestinal Neoplasms,
pubmed-meshheading:14666711-Gene Therapy,
pubmed-meshheading:14666711-HT29 Cells,
pubmed-meshheading:14666711-Humans,
pubmed-meshheading:14666711-Keratins,
pubmed-meshheading:14666711-Luciferases,
pubmed-meshheading:14666711-Mucin-1,
pubmed-meshheading:14666711-Mucin-2,
pubmed-meshheading:14666711-Mucins,
pubmed-meshheading:14666711-Peptides,
pubmed-meshheading:14666711-Promoter Regions, Genetic,
pubmed-meshheading:14666711-Proteins,
pubmed-meshheading:14666711-Telomerase,
pubmed-meshheading:14666711-Transfection,
pubmed-meshheading:14666711-Tumor Suppressor Proteins
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pubmed:articleTitle |
Assessing optimal promoter activity for constructs in gastrointestinal gene therapy.
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pubmed:affiliation |
Division of Molecular Genetics, University of Tübingen, Wilhelmstr 27, D-72074 Tübingen, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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