|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0011847,
umls-concept:C0015376,
umls-concept:C0026336,
umls-concept:C0026339,
umls-concept:C0034693,
umls-concept:C0034721,
umls-concept:C0035298,
umls-concept:C0035309,
umls-concept:C0392756,
umls-concept:C1504902,
umls-concept:C1801960
|
|
pubmed:issue |
1
|
|
pubmed:dateCreated |
2004-1-16
|
|
pubmed:abstractText |
Retinal vascular leakage is an early pathological feature in diabetic retinopathy and can lead to macular oedema and loss of vision. Previously we have shown that plasminogen kringle 5 (K5), an angiogenic inhibitor, inhibits retinal neovascularisation in the rat model of oxygen-induced retinopathy (OIR). The purpose of this study was to examine the effect of K5 on vascular leakage in the retina.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jan
|
|
pubmed:issn |
0012-186X
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
47
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
124-31
|
|
pubmed:dateRevised |
2007-11-14
|
|
pubmed:meshHeading |
pubmed-meshheading:14666366-Angiogenesis Inhibitors,
pubmed-meshheading:14666366-Animals,
pubmed-meshheading:14666366-Diabetes Mellitus, Experimental,
pubmed-meshheading:14666366-Diabetic Retinopathy,
pubmed-meshheading:14666366-Immunohistochemistry,
pubmed-meshheading:14666366-Insulin-Like Growth Factor I,
pubmed-meshheading:14666366-Peptide Fragments,
pubmed-meshheading:14666366-Plasminogen,
pubmed-meshheading:14666366-Rats,
pubmed-meshheading:14666366-Rats, Inbred BN,
pubmed-meshheading:14666366-Vascular Endothelial Growth Factor A
|
|
pubmed:year |
2004
|
|
pubmed:articleTitle |
Plasminogen kringle 5 reduces vascular leakage in the retina in rat models of oxygen-induced retinopathy and diabetes.
|
|
pubmed:affiliation |
Department of Medicine, The University of Oklahoma Health Science Center, 941 Stanton L. Young Blvd., BSEB 328B, Oklahoma City, OK 73104-5043, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
