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pubmed-article:14665560pubmed:abstractTextMyocardial potassium channels are complexes formed by different subunits. The subunit composition may influence the cardiotoxic action of local anaesthetics. The effects of amide local anaesthetics on HERG channels co-expressed with the putative subunit MiRP1 have not been established. It is also unclear if the common polymorphism MiRP1(T8A) that predisposes individuals to drug-induced cardiac arrhythmia increases local-anaesthetic sensitivity of HERG/MiRP1 channels. This may suggest the presence of genetic risk factors for local-anaesthetic-induced cardiac arrhythmia.lld:pubmed
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pubmed-article:14665560pubmed:articleTitleLocal anaesthetic sensitivities of cloned HERG channels from human heart: comparison with HERG/MiRP1 and HERG/MiRP1 T8A.lld:pubmed
pubmed-article:14665560pubmed:affiliationDepartment of Anaesthesiology, University Hospital Hamburg Eppendorf, Martinistr. 52, D-20251 Hamburg, Germany. patrick.friederich@zmnh.uni-hamburg.delld:pubmed
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