|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
1
|
|
pubmed:dateCreated |
2003-12-10
|
|
pubmed:abstractText |
Myocardial potassium channels are complexes formed by different subunits. The subunit composition may influence the cardiotoxic action of local anaesthetics. The effects of amide local anaesthetics on HERG channels co-expressed with the putative subunit MiRP1 have not been established. It is also unclear if the common polymorphism MiRP1(T8A) that predisposes individuals to drug-induced cardiac arrhythmia increases local-anaesthetic sensitivity of HERG/MiRP1 channels. This may suggest the presence of genetic risk factors for local-anaesthetic-induced cardiac arrhythmia.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Amides,
http://linkedlifedata.com/resource/pubmed/chemical/Anesthetics, Local,
http://linkedlifedata.com/resource/pubmed/chemical/Bupivacaine,
http://linkedlifedata.com/resource/pubmed/chemical/Cation Transport Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/ERG protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/ERG1 potassium channel,
http://linkedlifedata.com/resource/pubmed/chemical/Ether-A-Go-Go Potassium Channels,
http://linkedlifedata.com/resource/pubmed/chemical/KCNH6 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Potassium Channels,
http://linkedlifedata.com/resource/pubmed/chemical/Potassium Channels, Voltage-Gated,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/levobupivacaine,
http://linkedlifedata.com/resource/pubmed/chemical/potassium channel protein I(sk),
http://linkedlifedata.com/resource/pubmed/chemical/ropivacaine
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jan
|
|
pubmed:issn |
0007-0912
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
92
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
93-101
|
|
pubmed:dateRevised |
2008-10-28
|
|
pubmed:meshHeading |
pubmed-meshheading:14665560-Amides,
pubmed-meshheading:14665560-Anesthetics, Local,
pubmed-meshheading:14665560-Animals,
pubmed-meshheading:14665560-Bupivacaine,
pubmed-meshheading:14665560-CHO Cells,
pubmed-meshheading:14665560-Cation Transport Proteins,
pubmed-meshheading:14665560-Cloning, Molecular,
pubmed-meshheading:14665560-Cricetinae,
pubmed-meshheading:14665560-Cricetulus,
pubmed-meshheading:14665560-DNA-Binding Proteins,
pubmed-meshheading:14665560-Dose-Response Relationship, Drug,
pubmed-meshheading:14665560-Electrophysiology,
pubmed-meshheading:14665560-Ether-A-Go-Go Potassium Channels,
pubmed-meshheading:14665560-Heart,
pubmed-meshheading:14665560-Humans,
pubmed-meshheading:14665560-Mutagenesis, Site-Directed,
pubmed-meshheading:14665560-Myocardium,
pubmed-meshheading:14665560-Patch-Clamp Techniques,
pubmed-meshheading:14665560-Potassium Channels,
pubmed-meshheading:14665560-Potassium Channels, Voltage-Gated,
pubmed-meshheading:14665560-Trans-Activators,
pubmed-meshheading:14665560-Transfection
|
|
pubmed:year |
2004
|
|
pubmed:articleTitle |
Local anaesthetic sensitivities of cloned HERG channels from human heart: comparison with HERG/MiRP1 and HERG/MiRP1 T8A.
|
|
pubmed:affiliation |
Department of Anaesthesiology, University Hospital Hamburg Eppendorf, Martinistr. 52, D-20251 Hamburg, Germany. patrick.friederich@zmnh.uni-hamburg.de
|
|
pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|
