| pubmed-article:14664828 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:14664828 | lifeskim:mentions | umls-concept:C0228575 | lld:lifeskim |
| pubmed-article:14664828 | lifeskim:mentions | umls-concept:C0521329 | lld:lifeskim |
| pubmed-article:14664828 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:14664828 | lifeskim:mentions | umls-concept:C0728940 | lld:lifeskim |
| pubmed-article:14664828 | lifeskim:mentions | umls-concept:C1521797 | lld:lifeskim |
| pubmed-article:14664828 | lifeskim:mentions | umls-concept:C0015252 | lld:lifeskim |
| pubmed-article:14664828 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:14664828 | lifeskim:mentions | umls-concept:C0205124 | lld:lifeskim |
| pubmed-article:14664828 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:14664828 | pubmed:dateCreated | 2003-12-10 | lld:pubmed |
| pubmed-article:14664828 | pubmed:abstractText | Primary afferent A-fiber stimulation normally evokes fast mono- or polysynaptic EPSCs of short duration. However, in the presence of the GABA(A) receptor antagonist bicuculline, repetitive, long lasting, polysynaptic EPSCs can be observed following the initial, fast response. A-fiber-induced ERK activation is also facilitated in the presence of bicuculline. The frequency of miniature EPSCs and the amplitude of the monosynaptic A-fiber-evoked EPSCs are not affected by bicuculline or the GABA(A) receptor agonist muscimol, suggesting that GABA(A) receptors located on somatodendritic sites of excitatory interneurons are critical for this action. Bicuculline-enhanced polysynaptic EPSCs are completely eliminated by NMDA receptor antagonists APV and ketamine, as was the augmented ERK activation. This NMDA receptor-dependent phenomenon may contribute to bicuculline-induced allodynia or hyperalgesia, as well as the hypersensitivity observed in neuropathic pain patients. | lld:pubmed |
| pubmed-article:14664828 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14664828 | pubmed:language | eng | lld:pubmed |
| pubmed-article:14664828 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14664828 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:14664828 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:14664828 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:14664828 | pubmed:issn | 1044-7431 | lld:pubmed |
| pubmed-article:14664828 | pubmed:author | pubmed-author:OkamotoManabu... | lld:pubmed |
| pubmed-article:14664828 | pubmed:author | pubmed-author:JiRu-RongRR | lld:pubmed |
| pubmed-article:14664828 | pubmed:author | pubmed-author:WoolfClifford... | lld:pubmed |
| pubmed-article:14664828 | pubmed:author | pubmed-author:AtakaToyofumi... | lld:pubmed |
| pubmed-article:14664828 | pubmed:author | pubmed-author:BabaHiroshiH | lld:pubmed |
| pubmed-article:14664828 | pubmed:author | pubmed-author:MooreKimberly... | lld:pubmed |
| pubmed-article:14664828 | pubmed:author | pubmed-author:KohnoTatsuroT | lld:pubmed |
| pubmed-article:14664828 | pubmed:author | pubmed-author:WakaiAyakoA | lld:pubmed |
| pubmed-article:14664828 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:14664828 | pubmed:volume | 24 | lld:pubmed |
| pubmed-article:14664828 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:14664828 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:14664828 | pubmed:pagination | 818-30 | lld:pubmed |
| pubmed-article:14664828 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:14664828 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:14664828 | pubmed:articleTitle | Removal of GABAergic inhibition facilitates polysynaptic A fiber-mediated excitatory transmission to the superficial spinal dorsal horn. | lld:pubmed |
| pubmed-article:14664828 | pubmed:affiliation | Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA. baba@med.niigata-u.ac.jp | lld:pubmed |
| pubmed-article:14664828 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:14664828 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:14664828 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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