|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
3
|
|
pubmed:dateCreated |
2003-12-10
|
|
pubmed:abstractText |
Primary afferent A-fiber stimulation normally evokes fast mono- or polysynaptic EPSCs of short duration. However, in the presence of the GABA(A) receptor antagonist bicuculline, repetitive, long lasting, polysynaptic EPSCs can be observed following the initial, fast response. A-fiber-induced ERK activation is also facilitated in the presence of bicuculline. The frequency of miniature EPSCs and the amplitude of the monosynaptic A-fiber-evoked EPSCs are not affected by bicuculline or the GABA(A) receptor agonist muscimol, suggesting that GABA(A) receptors located on somatodendritic sites of excitatory interneurons are critical for this action. Bicuculline-enhanced polysynaptic EPSCs are completely eliminated by NMDA receptor antagonists APV and ketamine, as was the augmented ERK activation. This NMDA receptor-dependent phenomenon may contribute to bicuculline-induced allodynia or hyperalgesia, as well as the hypersensitivity observed in neuropathic pain patients.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Nov
|
|
pubmed:issn |
1044-7431
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
24
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
818-30
|
|
pubmed:dateRevised |
2009-11-19
|
|
pubmed:meshHeading |
pubmed-meshheading:14664828-Animals,
pubmed-meshheading:14664828-Denervation,
pubmed-meshheading:14664828-Disease Models, Animal,
pubmed-meshheading:14664828-Excitatory Amino Acid Antagonists,
pubmed-meshheading:14664828-Excitatory Postsynaptic Potentials,
pubmed-meshheading:14664828-GABA Agonists,
pubmed-meshheading:14664828-GABA Antagonists,
pubmed-meshheading:14664828-Male,
pubmed-meshheading:14664828-Mitogen-Activated Protein Kinases,
pubmed-meshheading:14664828-Nerve Fibers, Myelinated,
pubmed-meshheading:14664828-Neural Inhibition,
pubmed-meshheading:14664828-Neuralgia,
pubmed-meshheading:14664828-Peripheral Nervous System Diseases,
pubmed-meshheading:14664828-Posterior Horn Cells,
pubmed-meshheading:14664828-Rats,
pubmed-meshheading:14664828-Rats, Sprague-Dawley,
pubmed-meshheading:14664828-Receptors, GABA-A,
pubmed-meshheading:14664828-Receptors, N-Methyl-D-Aspartate,
pubmed-meshheading:14664828-Sciatic Neuropathy,
pubmed-meshheading:14664828-Synapses,
pubmed-meshheading:14664828-Synaptic Transmission,
pubmed-meshheading:14664828-gamma-Aminobutyric Acid
|
|
pubmed:year |
2003
|
|
pubmed:articleTitle |
Removal of GABAergic inhibition facilitates polysynaptic A fiber-mediated excitatory transmission to the superficial spinal dorsal horn.
|
|
pubmed:affiliation |
Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA. baba@med.niigata-u.ac.jp
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
