Linked Life Data

14662411

Source:http://linkedlifedata.com/resource/pubmed/id/14662411

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2003-12-9
pubmed:abstractText
Heme oxygenase-1 (HO-1) is known as a stress-inducible protein. The present study was designed to investigate the relationship between HO-1 expression levels and clinical features of tongue cancer by using HO-1 responsiveness to stress as a clinical indicator. One-hundred and twelve biopsy samples from tongue squamous cell carcinomas were analyzed semiquantitatively by immunohistochemistry. Correlations between the expression level of HO-1 and the clinical features of tumors were statistically analyzed. Fifty-four cases with surgical confirmation of lymph node metastasis were examined for the association between cervical lymph node metastasis (pN) and other clinical features, including the HO-1 expression level, using logistic regression. The low HO-1 expression group contained significantly more undifferentiated samples (P=0.04) and pN positive cases (P=0.01) by univariate analysis. The low HO-1 expression group (odds ratio=8.49; 95% confidence interval=1.64-44.09, P=0.01) and an endophytic shape (odds ratio=16.79; 95% confidence interval=1.77-159.53, P=0.01) were significantly associated with an increased risk of developing lymph node metastasis by multivariate analysis. Low HO-1 expression was associated with lymph node metastasis. The expression profile suggests HO-1 could be used clinically as a marker for tumors possessing the potential for lymph node metastasis. This method could prove useful as an adjuvant method to detect lymph node metastasis and may help reduce the number of surgeries by indicating when surgery is unnecessary.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
1368-8375
pubmed:author
pubmed:issnType
Print
pubmed:volume
40
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
21-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Heme oxygenase-1 expression predicts cervical lymph node metastasis of tongue squamous cell carcinomas.
pubmed:affiliation
Department of Oral and Maxillofacial Surgery, Institute of Clinical Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba-shi, Ibaraki-ken, 305-8575, Japan. ytony@md.tsukuba.ac.jp
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't